Department of Radiation Oncology, Stanford University, USA.
RaySearch Laboratories AB, Stockholm, Sweden.
Radiother Oncol. 2016 Apr;119(1):154-8. doi: 10.1016/j.radonc.2016.01.017. Epub 2016 Feb 18.
To assess the quality of very-high energy electron (VHEE) scanning pencil beam radiation therapy in relation to state-of-the-art volumetric modulated arc therapy (VMAT) and to determine the extent of its application.
We planned five clinical cases with VHEE scanning pencil beams of 100 and 120MeV, equally distributed in a coplanar arrangement around the patient. The clinical cases included acoustic neuroma, and liver, lung, esophagus, and anal cancer cases. We performed Monte Carlo (MC) dose calculations and we optimized the dose in a research version of RayStation. VHEE plan performance was compared against clinically delivered VMAT.
With equal target coverage, mean doses to organs at risk (OARs) were on average 22% lower for the VHEE plans compared to the VMAT plans. Dose conformity was equal or superior compared to the VMAT plans and integral dose to the body was in average 14% (9-22%) lower for the VHEE plans.
The dosimetric advantages of VHEE as demonstrated for a variety of clinical cases, combined with the theoretical ultra fast treatment delivery, afford VHEE scanning pencil beam radiotherapy a suitable and potentially superior alternative for cancer radiotherapy.
评估超高能电子（VHEE）扫描铅笔束放射治疗与最先进的容积调强弧形治疗（VMAT）的质量，并确定其应用程度。
我们计划对 5 例临床病例进行 VHEE 扫描铅笔束治疗，能量为 100MeV 和 120MeV，在患者周围共面分布。临床病例包括听神经瘤、肝脏、肺部、食管和肛门癌。我们进行了蒙特卡罗（MC）剂量计算，并在 RayStation 的研究版本中进行了剂量优化。VHEE 计划的性能与临床提供的 VMAT 进行了比较。
在相同的靶区覆盖情况下，与 VMAT 计划相比，VHEE 计划对危及器官（OARs）的平均剂量低 22%。与 VMAT 计划相比，剂量适形性相等或更高，而全身积分剂量平均低 14%（9-22%）。
VHEE 的剂量学优势已在各种临床病例中得到证实，结合理论上的超快治疗速度，VHEE 扫描铅笔束放射治疗为癌症放射治疗提供了一种合适的、潜在更优越的替代方法。
