Ronga Maria Grazia, Cavallone Marco, Patriarca Annalisa, Leite Amelia Maia, Loap Pierre, Favaudon Vincent, Créhange Gilles, De Marzi Ludovic
Centre de Protonthérapie d'Orsay, Department of Radiation Oncology, Campus Universitaire, Institut Curie, PSL Research University, 91898 Orsay, France.
Thales AVS Microwave & Imaging Sub-Systems, 78141 Vélizy-Villacoublay, France.
Cancers (Basel). 2021 Sep 30;13(19):4942. doi: 10.3390/cancers13194942.
The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. In particular, very high-energy electron (VHEE) radiotherapy, in the energy range of 100 to 250 MeV, first proposed in the 2000s, would be particularly interesting both from a ballistic and biological point of view for the establishment of this new type of irradiation technique. In this review, we examine and summarize the current knowledge on VHEE radiotherapy and provide a synthesis of the studies that have been published on various experimental and simulation works. We will also consider the potential for VHEE therapy to be translated into clinical contexts.
开发创新方法以降低健康组织对辐射的敏感性，同时保持对肿瘤的治疗效果，这对于放射治疗疗效的进展至关重要。近期的方法学发展与创新，例如扫描束、超高剂量率以及非常高能量的电子，这些在新的加速器上可能同时具备，使得超高剂量率短脉冲（FLASH）放疗在放射生物学方面的潜在优势得以被考虑用于放射治疗。特别是，在21世纪初首次提出的能量范围为100至250兆电子伏特的非常高能量电子（VHEE）放疗，从弹道学和生物学角度来看，对于建立这种新型照射技术都将特别有意义。在本综述中，我们审视并总结了关于VHEE放疗的当前知识，并对已发表的各种实验和模拟研究进行了综合。我们还将探讨VHEE疗法转化为临床应用的潜力。
