Risk factors for patients with multiple synchronous primary cancers involving oral and oropharyngeal subsites.
作者信息
Feng Zhien, Xu Qiao Shi, Niu Qi Fang, Qin Li Zheng, Li Jin Zhong, Su Ming, Li Hua, Han Zhengxue
机构信息
Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Apr;121(4):360-6. doi: 10.1016/j.oooo.2015.10.031. Epub 2015 Nov 14.
OBJECTIVE
To evaluate risk factors and prognosis for multiple synchronous primary cancers (MSPCs) associated with head and neck squamous cell carcinoma.
STUDY DESIGN
The retrospective study included 1623 patients.
RESULTS
The most common MSPC site involved was the head and neck region. The presence of multiple oral dysplastic lesions (P < .001) was the sole risk factor for the occurrence of MSPCs. A multivariate survival analysis showed that the pathologic grade (P = .003) was an independent predictive factor for the 5-year disease-specific survival of patients with MSPCs. A Kaplan-Meier analysis showed that the 5-year disease-specific survival of patients who developed MSPCs was worse than that of patients who did not develop MSPCs (P = .020).
CONCLUSIONS
MSPCs are a significant negative prognostic factor for patients with head and neck squamous cell carcinoma. However, a worse prognosis is predicted for patients with MSPCs with several features: a higher pathologic grade, a more aggressive growth pattern, male gender plus a tobacco or alcohol habit, and no multiple oral dysplastic lesions.
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