Cheng Ji, Gao Jinbo, Tao Kaixiong
Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038 China.
Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.
Sci Rep. 2016 Feb 22;6:22184. doi: 10.1038/srep22184.
Gli1 is a downstream transcriptional factor of Sonic hedgehog pathway in mammalians, and has been recognized as a proliferative indicator of carcinogenesis. However, its actual role in prognosis among solid malignancies remains unclear. Therefore we performed this meta-analysis aiming to discover the correlation between Gli1 positivity and clinical prognosis in patients suffering from diverse carcinomas. A total of 39 studies containing 4496 cases were selected into our quantitative analysis via electronic database search. Original data of 3-year, 5-year, 10-year overall survival and disease-free survival were extracted and calculated using odds ratio and Mantel-Haenszel model. Subgroup analysis was also conducted to clarify the possible confounding factors. P < 0.05 was considered significant in statistics. Gli1 redundancy was associated with worse 3-year, 5-year, 10-year overall survival and disease-free survival in solid malignancies. Different source regions, sample-size, mean-age and detection approaches had no impact on the negative prognostic effect of Gli1 over-expression. Nevertheless, stratified by cancer type and subcellular localization, cytoplasmic Gli1 expression and Gli1 positivity in intracranial tumors was not correlated to poorer 3-year and 5-year prognosis. The over-expression of Gli1 is a credible indicator of poorer prognosis in most of solid malignancies, irrespective of intracranial tumors.
Gli1是哺乳动物中 Sonic hedgehog信号通路的下游转录因子，已被公认为致癌作用的增殖指标。然而，其在实体恶性肿瘤预后中的实际作用仍不清楚。因此，我们进行了这项荟萃分析，旨在发现Gli1阳性与各种癌症患者临床预后之间的相关性。通过电子数据库检索，共筛选出39项研究，包含4496例患者纳入定量分析。提取3年、5年、10年总生存率和无病生存率的原始数据，并使用比值比和Mantel-Haenszel模型进行计算。还进行了亚组分析以阐明可能的混杂因素。统计学上P < 0.05被认为具有显著性。Gli1高表达与实体恶性肿瘤较差的3年、5年、10年总生存率和无病生存率相关。不同的来源地区、样本量、平均年龄和检测方法对Gli1过表达的不良预后影响无作用。然而，按癌症类型和亚细胞定位分层后，颅内肿瘤中细胞质Gli1表达和Gli1阳性与较差的3年和5年预后无关。Gli1过表达是大多数实体恶性肿瘤（不包括颅内肿瘤）预后较差的可靠指标。
