Bouée Stéphane, Emery Corinne, Samson Adeline, Gourmelen Julie, Bailly Cécile, Cotté François-Emery
Cemka, 43 bd du Maréchal Joffre, 92340 Bourg-la-Reine, France.
Paris-Dauphine University, Paris, France ; Bristol-Myers Squibb, Rueil-Malmaison, France.
Thromb J. 2016 Feb 19;14:4. doi: 10.1186/s12959-016-0078-0. eCollection 2016.
Data estimating the annual incidence of venous thromboembolism (VTE) in France, taking into account both hospital and community settings, are very lacking. This study aimed to estimate the annual incidence of VTE (pulmonary embolism (PE) and deep vein thrombosis (DVT)) in France in 2011 in "real world" population.
This was a longitudinal insurance claims study of the incidence of VTE in France over 2 years (2010 and 2011). The data analysis was performed using the EGB (Echantillon Généraliste des Bénéficiaires) database, a randomly selected sample of the French national insurance database (CNAMTS) which covers 77 % of the population. All adult patients experiencing a VTE event during the study period were analysed. Recurrence rate of VTE and all-cause mortality rate were also estimated over a 12-month follow-up period.
The estimated annual incidence of VTE in France was 184.0 per 100 000 subjects, corresponding to a total of 119 670 events countrywide. The estimated incidence of DVT and PE were respectively 119.8 and 64.2 per 100 000 subjects. Annual recurrence of VTE was reported in 5.5 % (n = 99) patients, with a significantly higher recurrence rate in patients with PE than those with DVT (p = 0.02). Overall, 6.2 % (n = 112) of patients had died over the 12-month follow-up (respectively 10.2 and 7.7 % of patients with DVT and PE).
To our knowledge, this analysis is the first to estimate the annual incidence of VTE in France using exhaustive data from the EGB database. This has allowed the incidence of DVT in the community to be documented, which to date has not been characterised. Previous studies in France have been limited to the hospital setting and have yielded incidence rates comparable to ours.
This analysis is the first to estimate the annual incidence of VTE in France using exhaustive data from the EGB database. This study showed that the incidence and the burden of the disease remains elevated.
目前非常缺乏同时考虑医院和社区环境来估算法国静脉血栓栓塞症（VTE）年发病率的数据。本研究旨在估算2011年法国“真实世界”人群中VTE（肺栓塞（PE）和深静脉血栓形成（DVT））的年发病率。
这是一项对法国2年（2010年和2011年）内VTE发病率的纵向保险索赔研究。数据分析使用EGB（受益人的一般样本）数据库，这是法国国家保险数据库（CNAMTS）的一个随机抽样样本，覆盖77%的人口。对研究期间发生VTE事件的所有成年患者进行了分析。还在12个月的随访期内估算了VTE的复发率和全因死亡率。
法国VTE的估计年发病率为每10万受试者184.0例，相当于全国共有119670例。DVT和PE的估计发病率分别为每10万受试者119.8例和64.2例。5.5%（n = 99）的患者报告有VTE年复发，PE患者的复发率显著高于DVT患者（p = 0.02）。总体而言，6.2%（n = 112）的患者在12个月的随访期内死亡（DVT和PE患者分别为10.2%和7.7%）。
据我们所知，本分析首次使用EGB数据库的详尽数据估算了法国VTE的年发病率。这使得社区中DVT的发病率得以记录，而迄今为止这方面尚无特征描述。法国以前的研究仅限于医院环境，所得发病率与我们的相当。
本分析首次使用EGB数据库的详尽数据估算了法国VTE的年发病率。这项研究表明该疾病的发病率和负担仍然很高。
