联芳基磺酰氟的水上合成
On-Water Synthesis of Biaryl Sulfonyl Fluorides.
作者信息
Chinthakindi Praveen K, Kruger Hendrik G, Govender Thavendran, Naicker Tricia, Arvidsson Per I
机构信息
Catalysis and Peptide Research Unit, University of KwaZulu-Natal , Durban, 4041, South Africa.
Science for Life Laboratory, Drug Discovery & Development Platform & Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , SE-171 21 Stockholm, Sweden.
出版信息
J Org Chem. 2016 Mar 18;81(6):2618-23. doi: 10.1021/acs.joc.5b02770. Epub 2016 Feb 29.
Herein, we report an efficient, ligand-free, and additive-free Suzuki-Miyaura coupling that is compatible with the aromatic sulfonyl fluoride functional group. The protocol proceeds at room temperature, on water, and offers facile access to a wide range of biaryl sulfonyl fluorides as bioorthogonal "click" reagents.
在此，我们报道了一种高效、无配体且无添加剂的铃木-宫浦偶联反应，该反应与芳基磺酰氟官能团兼容。该反应在室温下于水相中进行，能够方便地合成多种作为生物正交“点击”试剂的联芳基磺酰氟。
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