Li Xin-Qing, Liao Qian-Qian, Lai Jun, Liao Yuan-Yue
Department of Pharmacy, Ganzhou People's Hospital, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou, China.
Department of Pharmacy, People's Hospital of Guilin, Guilin, China.
Front Chem. 2023 Aug 25;11:1267223. doi: 10.3389/fchem.2023.1267223. eCollection 2023.
Sulfonylaniline motif plays an important role in pharmaceutical sciences. Developed methods towards this structure are typically lack of good modifiability and stability. In this study, visible-light-mediated sulfonylation of aniline using sulfonyl fluoride as a modifiable and stable sulfonylation reagent is described. A variety of substituted sulfonylanilines were synthesized under mild reaction conditions with moderate to good efficiency. The example of late-stage sulfonylation highlighted the advantage of using sulfonyl fluoride as a sulfonylation reagent. In addition, the crucial influence of counterions on the photocatalyst observed in this system would inspire further research on the photochemistry of sulfonyl fluoride.
磺酰苯胺基序在药物科学中起着重要作用。针对这种结构已开发的方法通常缺乏良好的可修饰性和稳定性。在本研究中，描述了使用磺酰氟作为可修饰且稳定的磺酰化试剂，通过可见光介导的苯胺磺酰化反应。在温和的反应条件下，以中等至良好的效率合成了多种取代的磺酰苯胺。后期磺酰化的实例突出了使用磺酰氟作为磺酰化试剂的优势。此外，在该体系中观察到的抗衡离子对光催化剂的关键影响将激发对磺酰氟光化学的进一步研究。
