Kuranov A B, Kozhamkulov U A, Vavilov M N, Belova E S, Bismilda V L, Alenova A H, Ismailov S S, Momynaliev K T
National Center for Biotechnology, Astana, Kazakhstan.
Tissue Antigens. 2014 Feb;83(2):106-12. doi: 10.1111/tan.12279. Epub 2014 Jan 7.
The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Some studies have reported that HLA class II genes play a strong role in severe cases of pulmonary tuberculosis (PTB) in several populations. Thus the aim of the study was to compare the HLA-class II alleles of patients with drug resistant tuberculosis with those of healthy controls from the same ethnic group in Kazakhstan. The aim of the present study was to evaluate the correlation of HLA-class II alleles by patients with drug resistant tuberculosis and the healthy controls of the same ethnic group in Kazakhstan. The HLA-class II alleles of 76 patients with tuberculosis (TB) and 157 healthy volunteers were investigated using sequence-based typing (SBT)-method. HLA-DQA103:02 HLA-DRB108:01 and DRB1*08:03 occurred more frequently (P = 0.05) in patients with drug resistant tuberculosis than in controls. We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis.
人类白细胞抗原（HLA）系统在免疫反应调节中起主要作用，因为它参与抵御病原体。一些研究报告称，HLA II类基因在若干人群的重症肺结核（PTB）中起重要作用。因此，本研究的目的是比较哈萨克斯坦耐药结核病患者与来自同一民族的健康对照者的HLA II类等位基因。本研究的目的是评估哈萨克斯坦耐药结核病患者与同一民族健康对照者的HLA II类等位基因的相关性。采用基于序列的分型（SBT）方法对76例结核病（TB）患者和157名健康志愿者的HLA II类等位基因进行了研究。HLA-DQA103:02、HLA-DRB108:01和DRB1*08:03在耐药结核病患者中出现的频率高于对照组（P = 0.05）。我们观察到某些HLA等位基因与哈萨克人群特有的结核病之间可能存在关联。需要进一步研究，使用更多的耐药结核病患者来证实我们的发现。
