Benedikz E, Blöndal H, Jóhannesson G, Guomundsson G, Guomundsson G
Department of Anatomy, University of Iceland, Landspítalinn.
Prog Clin Biol Res. 1989;317:517-22.
Brain biopsies from two patients with non-hereditary cerebral hemorrhages and eighty autopsied cases with the clinical diagnosis of dementia are presented. The biopsied cases, both males aged 64 and 59, had a sudden onset of cerebral hemorrhage, mild progressive dementia and cystatin C cerebral amyloid angiopathy. Of the autopsied cases 59 had senile plaques and cerebral amyloid angiopathy was also found in 36 of them. Both senile plaques and the blood vessel amyloid stained positively with beta-protein antibodies, and five of them also showed a positive reaction to cystatin C antibodies. These cystatin C positive cases were three males aged 76, 80 and 83, and one female 93 years old and the fifth case was a female aged 47 with Down's syndrome.
本文展示了两名非遗传性脑出血患者的脑活检样本，以及八十例临床诊断为痴呆症的尸检病例。活检病例均为男性，年龄分别为64岁和59岁，均突然发生脑出血，伴有轻度进行性痴呆和胱抑素C脑淀粉样血管病。在尸检病例中，59例有老年斑，其中36例也发现有脑淀粉样血管病。老年斑和血管淀粉样物质均用β蛋白抗体染色呈阳性，其中五例对胱抑素C抗体也呈阳性反应。这些胱抑素C阳性病例包括三名年龄分别为76岁、80岁和83岁的男性，一名93岁的女性，第五例是一名47岁患有唐氏综合征的女性。
