Axenov-Gribanov Denis V, Voytsekhovskaya Irina V, Tokovenko Bogdan T, Protasov Eugeniy S, Gamaiunov Stanislav V, Rebets Yuriy V, Luzhetskyy Andriy N, Timofeyev Maxim A
Irkutsk State University, Institute of Biology, Irkutsk, Russia.
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Saarbrucken, Germany.
PLoS One. 2016 Feb 22;11(2):e0149216. doi: 10.1371/journal.pone.0149216. eCollection 2016.
Actinobacteria isolated from unstudied ecosystems are one of the most interesting and promising sources of novel biologically active compounds. Cave ecosystems are unusual and rarely studied. Here, we report the isolation and characterization of ten new actinobacteria strains isolated from an ancient underground lake and moonmilk speleothem from the biggest conglomeratic karstic cave in Siberia with a focus on the biological activity of the obtained strains and the metabolite dereplication of one active strain. Streptomyces genera isolates from moonmilk speleothem demonstrated antibacterial and antifungal activities. Some of the strains were able to inhibit the growth of pathogenic Candida albicans.
从未经研究的生态系统中分离出的放线菌是新型生物活性化合物最有趣且最具潜力的来源之一。洞穴生态系统不同寻常且鲜少被研究。在此，我们报告了从西伯利亚最大的砾岩岩溶洞穴中的一个古老地下湖和月奶石笋中分离出的10株新型放线菌菌株的分离与鉴定，重点关注所获菌株的生物活性以及一株活性菌株的代谢物去重复分析。从月奶石笋中分离出的链霉菌属菌株表现出抗菌和抗真菌活性。一些菌株能够抑制致病性白色念珠菌的生长。
