The novel tumor suppressor AIRAPL regulates IGF1R proteostasis.
作者信息
Osorio Fernando G, Freije José M P, López-Otín Carlos
机构信息
a Departamento de Bioquímica y Biología Molecular , Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo , Oviedo , Spain.
出版信息
Cell Cycle. 2016;15(7):873-4. doi: 10.1080/15384101.2016.1151725. Epub 2016 Feb 22.
Abstract
摘要
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本文引用的文献
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Targeting a regulator of protein homeostasis in myeloproliferative neoplasms.
Nat Med. 2016 Jan;22(1):20-1. doi: 10.1038/nm.4028.
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Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.
Nat Med. 2016 Jan;22(1):91-6. doi: 10.1038/nm.4013. Epub 2015 Dec 21.
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Proteasomal degradation of preemptive quality control (pQC) substrates is mediated by an AIRAPL-p97 complex.
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