Strid Jessica, McLean W H Irwin, Irvine Alan D
Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK.
Department of Dermatology and Genetic Medicine, School of Life Sciences, University of Dundee, Dundee, UK.
J Invest Dermatol. 2016 Mar;136(3):561-564. doi: 10.1016/j.jid.2015.12.025.
The mechanistic relationship between IL-4/IL-13 and skin barrier function has been of interest since the filaggrin discovery and the subsequent in vitro demonstration that IL-4 and IL-13 downregulate filaggrin expression in cultured keratinocytes. Hönzke and colleagues explore these interactions further. The effects of IL-4/ll-13 may be context dependent, with differing roles in homeostasis and in disease.
