Department of Dermatology and Allergology, Ludwig-Maximilian-University, 80337 Munich, Germany.
Clin Dermatol. 2010 Jan-Feb;28(1):62-6. doi: 10.1016/j.clindermatol.2009.04.004.
The pathophysiology of atopic dermatitis is still under discussion. Although it is widely accepted that environmental factors and a genetic predisposition are essential, the role of the innate and adaptive immune system and the functional cascade of the cells involved is still unclear. A concept that integrates all immune cells as equally essential has allure. In addition, barrier abnormalities due to mutations of the gene coding for filaggrin and down-regulation of antimicrobial peptides, such as LL-37 and beta-defensins 2 and 3, were very recently found to be relevant for the pathogenesis of atopic dermatitis.
特应性皮炎的病理生理学仍在讨论中。尽管人们普遍认为环境因素和遗传易感性是必不可少的，但先天和适应性免疫系统以及所涉及的细胞的功能级联的作用仍不清楚。一个将所有免疫细胞都视为同等重要的概念具有吸引力。此外，由于编码丝聚蛋白的基因突变和抗菌肽（如 LL-37 和β-防御素 2 和 3）的下调导致的屏障异常最近也被发现与特应性皮炎的发病机制有关。
