Odeh O I, Kuti M A, Fasunla A J, Nwaorgu O G
Department of Otorhinolaryngology, University College Hospital, Ibadan, Nigeria.
West Afr J Med. 2015 Jan-Mar;34(1):27-31.
The incidence of dyslipidemia is increasing worldwide due to changes in diet and lifestyle. The aetiological role of dyslipidemia in sensorineural hearing loss (SNHL) is unclear.
To determine the association between SNHL and dyslipidemia in adult Nigerian population.
This prospective case control study was carried out at ENT Department of University College Hospital Ibadan from August 2013 to May 2014.
The study involved consecutive adult patients (18-60 years) with SNHL. The controls were adults without SNHL matched for age, gender and socioeconomic status. Relevant clinical data were obtained. Hearing threshold was determined by standard method and fasting plasma lipid assayed for triglycerides (TG), total cholesterol (TC), high density and lipoprotein-cholesterol (HDL-C). The low density lipoprotein-cholesterol (LDL-C) was calculated from TG, TC and HDL-C using Freidewald's formulae. The values of <40mg/dl, >200mg/dl, >150mg/dl and >130mg/dl were considered abnormal for HDL-C, TC, TG and LDL-C respectively. Level of statistical significance was P<0.05.
There were 108 participants, consisting 57 (67.7%) cases and 51 (32.9%) controls with mean age of 37.911.3 years and 37.4 11.3-year respectively (p=0.708). Abnormalities in HDL-C values was the commonly observed in both cases (64.9%) and controls (76.5%).Thirty-six (63.2%) cases had severe to profound hearing loss. There was no significant correlation between lipid parameters and severity of SNHL.
The prevalence of dyslipidemia in adult patients with sensorineural hearing loss is similar to those with normal hearing. There appears to beno causal association between dyslipidemia and sensorineural hearing loss.
由于饮食和生活方式的改变，全球血脂异常的发病率正在上升。血脂异常在感音神经性听力损失（SNHL）中的病因学作用尚不清楚。
确定尼日利亚成年人群中SNHL与血脂异常之间的关联。
这项前瞻性病例对照研究于2013年8月至2014年5月在伊巴丹大学学院医院耳鼻喉科进行。
该研究纳入了连续性的成年SNHL患者（18 - 60岁）。对照组为无SNHL的成年人，在年龄、性别和社会经济地位方面进行匹配。获取相关临床数据。通过标准方法确定听力阈值，并检测空腹血浆脂质中的甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL - C）。使用弗赖德瓦尔德公式从TG、TC和HDL - C计算低密度脂蛋白胆固醇（LDL - C）。HDL - C、TC、TG和LDL - C的值分别<40mg/dl、>200mg/dl、>150mg/dl和>130mg/dl被视为异常。统计学显著性水平为P<0.05。
共有108名参与者，其中57例（67.7%）为病例组，51例（32.9%）为对照组，平均年龄分别为37.9±11.3岁和37.4±11.3岁（p = 0.708）。HDL - C值异常在病例组（64.9%）和对照组（76.5%）中均常见。36例（63.2%）病例有重度至极重度听力损失。脂质参数与SNHL严重程度之间无显著相关性。
成年感音神经性听力损失患者血脂异常的患病率与听力正常者相似。血脂异常与感音神经性听力损失之间似乎没有因果关联。
