[长链非编码RNA在非小细胞肺癌中的研究进展]
[Progress of Long Non-coding RNAs in Non-small Cell Lung Cancer].
作者信息
Fan Liming, Hu Zhidong
机构信息
Department of Medical Clinical Laboratory, Tianjin Medical University General Hospital, 300052 Tianjin, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2016 Feb;19(2):108-12. doi: 10.3779/j.issn.1009-3419.2016.02.10.
Abstract
Lung cancer related death is the most common cause of cancer death worldwide. Non-coding RNA has no protein coding capacity, but can play roles in a variety of biology. Long non-coding RNA (lncRNA) is at least 200 nt long. A variety of lncRNAs could promote or inhibit tumor development and progression in many tumors, including non-small cell lung cancer (NSCLC). Due to their fundamental role in regulating gene expression, they involve in biological mechanism of the tumor, and so they are expected to be new cancer biomarkers. In this review, we emphasized the roles of lncRNAs in NSCLC, and discuss them as diagnostic and prognostic markers and as therapeutic targets.
摘要
肺癌相关死亡是全球癌症死亡的最常见原因。非编码RNA没有蛋白质编码能力，但可在多种生物学过程中发挥作用。长链非编码RNA（lncRNA）长度至少为200个核苷酸。多种lncRNA可促进或抑制包括非小细胞肺癌（NSCLC）在内的多种肿瘤的发生发展。由于它们在调节基因表达中起重要作用，参与肿瘤的生物学机制，因此有望成为新的癌症生物标志物。在本综述中，我们着重阐述了lncRNA在NSCLC中的作用，并将其作为诊断和预后标志物以及治疗靶点进行讨论。
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