Pucheu-Haston Cherie M
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, 1909 Skip Bertman Drive, Baton Rouge, LA 70803.
Clin Dermatol. 2016 Mar-Apr;34(2):299-303. doi: 10.1016/j.clindermatol.2015.10.010. Epub 2015 Oct 24.
Dogs may develop a syndrome of spontaneous, inflammatory, pruritic dermatitis that shares many features with human atopic dermatitis, including a young age of onset, characteristic lesion distribution, immunoglobulin E sensitization to common environmental allergen sources, and evidence of epidermal barrier dysfunction. There are also several important differences between canine and human atopic dermatitis. Although dogs may suffer from multiple-organ hypersensitivity syndromes, there is no evidence that this species experiences the progressive evolution from cutaneous to respiratory allergy characteristic of the human atopic march. Despite the presence of epidermal barrier derangement, there is no significant association between canine atopic dermatitis and mutations in filaggrin. Finally, treatment of canine disease relies much less heavily on topical therapy than does its human counterpart, while allergy testing and allergen-specific immunotherapy provide an often essential component of effective clinical management of affected dogs.
犬类可能会患上一种自发性、炎症性、瘙痒性皮肤病综合征，该综合征与人类特应性皮炎有许多共同特征，包括发病年龄小、特征性皮损分布、对常见环境过敏原来源的免疫球蛋白E致敏，以及表皮屏障功能障碍的证据。犬类特应性皮炎和人类特应性皮炎之间也存在一些重要差异。尽管犬类可能患有多器官过敏综合征，但没有证据表明该物种会经历人类特应性进程中从皮肤过敏到呼吸道过敏的渐进演变。尽管存在表皮屏障紊乱，但犬类特应性皮炎与丝聚蛋白突变之间没有显著关联。最后，与人类疾病相比，犬类疾病的治疗对局部治疗的依赖程度要低得多，而过敏检测和过敏原特异性免疫疗法通常是受影响犬类有效临床管理的重要组成部分。
