微小RNA在金属致癌物诱导的细胞恶性转化和肿瘤发生中的作用。
The role of microRNAs in metal carcinogen-induced cell malignant transformation and tumorigenesis.
作者信息
Humphries Brock, Wang Zhishan, Yang Chengfeng
机构信息
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA; Cellular and Molecular Biology Graduate Program, Michigan State University, East Lansing, MI 48824, USA.
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA.
出版信息
Food Chem Toxicol. 2016 Dec;98(Pt A):58-65. doi: 10.1016/j.fct.2016.02.012. Epub 2016 Feb 20.
MicroRNAs (miRNAs), an important component of epigenetic mechanisms of carcinogenesis, have been shown to play crucial roles in cancer initiation, metastasis, prognosis and responses to drug treatment and may serve as biomarkers for early diagnosis of cancer and tools for cancer therapy. Metal carcinogens, such as arsenic, cadmium, hexavalent chromium and nickel, are well-established human carcinogens causing various cancers upon long term exposure. However, the mechanism of metal carcinogenesis has not been well understood, which limits our capability to effectively diagnose and treat human cancers resulting from chronic metal carcinogen exposure. Over recent years, the role of miRNAs in metal carcinogenesis has been actively explored and a growing body of evidence indicates the critical involvement of miRNAs in metal carcinogenesis. This review aims to discuss recent studies showing that miRNAs play important roles in metal carcinogen-induced cell malignant transformation and tumorigenesis. Some thoughts for future further studies in this field are also presented.
微小RNA（miRNA）是致癌作用表观遗传机制的重要组成部分，已被证明在癌症的发生、转移、预后以及对药物治疗的反应中发挥关键作用，并且可能作为癌症早期诊断的生物标志物和癌症治疗的工具。金属致癌物，如砷、镉、六价铬和镍，是公认的人类致癌物，长期接触会导致各种癌症。然而，金属致癌的机制尚未完全清楚，这限制了我们有效诊断和治疗因长期接触金属致癌物而导致的人类癌症的能力。近年来，人们积极探索了miRNA在金属致癌中的作用，越来越多的证据表明miRNA在金属致癌中起着关键作用。本综述旨在讨论最近的研究，这些研究表明miRNA在金属致癌物诱导的细胞恶性转化和肿瘤发生中发挥重要作用。本文还提出了该领域未来进一步研究的一些思路。
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