细胞凋亡、自噬和坏死性凋亡中的微小RNA

Su Zhenyi, Yang Zuozhang, Xu Yongqing, Chen Yongbin, Yu Qiang

Department of Biochemistry and Molecular Biology, Medical School, Southeast University, Nanjing, Jiangsu 210009, China.

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Oncotarget. 2015 Apr 20;6(11):8474-90. doi: 10.18632/oncotarget.3523.

MicroRNAs (miRNAs) are endogenous 22 nt non-coding RNAs that target mRNAs for cleavage or translational repression. Numerous miRNAs regulate programmed cell death including apoptosis, autophagy and necroptosis. We summarize how miRNAs regulate apoptotic, autophagic and necroptotic pathways and cancer progression. We also discuss how miRNAs link different types of cell death.

微小RNA（miRNA）是一类内源性的22个核苷酸的非编码RNA，可靶向mRNA进行切割或翻译抑制。许多miRNA可调节程序性细胞死亡，包括细胞凋亡、自噬和坏死性凋亡。我们总结了miRNA如何调节细胞凋亡、自噬和坏死性凋亡途径以及癌症进展。我们还讨论了miRNA如何连接不同类型的细胞死亡。