Johnson A G
University Surgical Unit, Royal Hallamshire Hospital, Sheffield, U.K.
Scand J Gastroenterol Suppl. 1989;165:36-43. doi: 10.3109/00365528909091229.
Five studies have shown that cisapride increased the antral motility index in the interdigestive and digestive states and three of these studies showed a stimulation of duodenal motility index and increased antroduodenal coordination. In normal volunteers and in patients with dyspepsia (223 subjects), both solid and liquid emptying is speeded by cisapride compared with placebo, and cisapride was as good as, or better than, metoclopramide at the same dosage. In studies in 37 diabetics with gastroparesis, both solid and liquid emptying were speeded and returned to normal, and cisapride was superior to metoclopramide. Solid emptying was speeded in patients with anorexia nervosa, chronic pseudo-obstruction and systemic sclerosis and the delay in gastric emptying induced by both morphine and dopamine was reversed. The effect of cisapride on bile reflux is still uncertain. Eight different methods of measuring gastric emptying were employed in these studies and they all gave similar results; the doses ranged from 2.5-10 mg i.v., and up to 20 mg orally.
五项研究表明，西沙必利可增加消化间期和消化期的胃窦运动指数，其中三项研究显示其可刺激十二指肠运动指数并增强胃窦十二指肠协调性。在正常志愿者和消化不良患者（223名受试者）中，与安慰剂相比，西沙必利可加快固体和液体排空，且在相同剂量下，西沙必利的效果与甲氧氯普胺相当或更佳。在对37名患有胃轻瘫的糖尿病患者进行的研究中，西沙必利可加快固体和液体排空并使其恢复正常，且其效果优于甲氧氯普胺。西沙必利可加快神经性厌食症、慢性假性肠梗阻和系统性硬化症患者的固体排空，并可逆转吗啡和多巴胺所致的胃排空延迟。西沙必利对胆汁反流的影响仍不确定。这些研究采用了八种不同的测量胃排空的方法，结果均相似；静脉注射剂量为2.5 - 10毫克，口服剂量可达20毫克。
