Department of Biology, Technion, Israel Institute of Technology, Haifa 3200003, Israel.
Department of Biology, Technion, Israel Institute of Technology, Haifa 3200003, Israel.
Semin Cell Dev Biol. 2016 May;53:101-14. doi: 10.1016/j.semcdb.2016.01.023. Epub 2016 Feb 20.
Fibroblast growth factor (FGF) signaling is involved in a multitude of biological processes, while impairment of FGF signaling is implicated in a variety of human diseases including developmental disorders and cancer. Therefore, it is not surprising that FGF activity is regulated at multiple and distinct levels. This review focuses on positive and negative modulation of the FGF signal exemplified by recently identified protein modulators anosmin-1, fibronectin-leucine-rich transmembrane protein 3 (FLRT3) and similar expression to FGF (Sef). We examine how these proteins regulate FGF signaling at multiple levels and across species. Finally, we describe the role of these regulators in human disease.
成纤维细胞生长因子 (FGF) 信号转导参与多种生物学过程，而 FGF 信号转导受损与多种人类疾病有关，包括发育障碍和癌症。因此，FGF 活性在多个不同水平受到调节并不奇怪。本综述重点介绍了最近发现的蛋白调节剂神经软蛋白-1、纤维连接蛋白富含亮氨酸跨膜蛋白 3 (FLRT3) 和类似 FGF 的表达 (Sef) 对 FGF 信号的正、负调节。我们研究了这些蛋白如何在多个水平和跨物种调节 FGF 信号转导。最后，我们描述了这些调节剂在人类疾病中的作用。
