Institute of Biomedicine, Department of Medical Sciences - iBiMED, University of Aveiro, Aveiro, Portugal.
CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Cell Commun Signal. 2023 Oct 16;21(1):290. doi: 10.1186/s12964-023-01284-0.
The fibroblast growth factor (FGF) family regulates various and important aspects of nervous system development, ranging from the well-established roles in neuronal patterning to more recent and exciting functions in axonal growth and synaptogenesis. In addition, FGFs play a critical role in axonal regeneration, particularly after spinal cord injury, confirming their versatile nature in the nervous system. Due to their widespread involvement in neural development, the FGF system also underlies several human neurological disorders. While particular attention has been given to FGFs in a whole-cell context, their effects at the axonal level are in most cases undervalued. Here we discuss the endeavor of the FGF system in axons, we delve into this neuronal subcompartment to provide an original view of this multipurpose family of growth factors in nervous system (dys)function. Video Abstract.
成纤维细胞生长因子（FGF）家族调节神经系统发育的各个重要方面，从神经元模式形成的既定作用到轴突生长和突触发生的更新颖和令人兴奋的功能。此外，FGF 在轴突再生中起关键作用，特别是在脊髓损伤后，这证实了它们在神经系统中的多功能性。由于它们广泛参与神经发育，FGF 系统也构成了几种人类神经疾病的基础。虽然人们特别关注整个细胞环境中的 FGF，但它们在轴突水平的作用在大多数情况下都被低估了。在这里，我们讨论了 FGF 系统在轴突中的作用，我们深入研究这个神经元亚区，以提供这个多功能生长因子家族在神经系统（功能障碍）中的新观点。视频摘要。
