Stürner Tomke, Tavosanis Gaia
Dendrite Differentiation, German Center for Neurodegenerative Diseases, 53115 Bonn, Germany.
Dendrite Differentiation, German Center for Neurodegenerative Diseases, 53115 Bonn, Germany
J Cell Biol. 2016 Feb 29;212(5):487-9. doi: 10.1083/jcb.201601091. Epub 2016 Feb 22.
Dynamic rearrangements of the actin cytoskeleton are crucial for cell shape and migration. In this issue, Squarr et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201508081) show that the cadherin superfamily protein Fat2 regulates actin-rich protrusions driving collective cell migration during Drosophila melanogaster egg morphogenesis through its interaction with the WAVE regulatory complex.
肌动蛋白细胞骨架的动态重排对于细胞形状和迁移至关重要。在本期杂志中,斯夸尔等人(2016年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201508081)表明,钙黏蛋白超家族蛋白Fat2通过与WAVE调节复合体相互作用,在黑腹果蝇卵子形态发生过程中调节富含肌动蛋白的突起,驱动集体细胞迁移。