Yanagisawa M, Masaki T
Trends Pharmacol Sci. 1989 Sep;10(9):374-8. doi: 10.1016/0165-6147(89)90011-4.
Endothelin-1 (ET-1), the first member of the newly discovered mammalian endothelin family of biologically active peptides, was originally identified as a 21 residue potent vasoconstrictor peptide in vascular endothelial cells. However, it has since been demonstrated to possess a wide variety of pharmacological activities in tissues both within and outside the cardiovascular system, and peptides with a striking similarity to ET-1 have been found to be the major toxic component of a snake venom. Moreover, recent studies have suggested that mammals including humans produce three distinct members of this peptide family, ET-1, ET-2 and ET-3, which may have different profiles of biological activity, and may act on distinct subtypes of endothelin receptor. Masashi Yanagisawa and Tomoh Masaki review the current status of the biochemistry and molecular biology of endothelin.
内皮素-1（ET-1）是新发现的哺乳动物生物活性肽内皮素家族的首个成员，最初被鉴定为血管内皮细胞中一种由21个氨基酸残基组成的强效血管收缩肽。然而，此后已证明它在心血管系统内外的组织中具有多种药理活性，并且已发现与ET-1具有显著相似性的肽是一种蛇毒的主要毒性成分。此外，最近的研究表明，包括人类在内的哺乳动物产生该肽家族的三个不同成员，即ET-1、ET-2和ET-3，它们可能具有不同的生物活性谱，并且可能作用于内皮素受体的不同亚型。柳泽正志和正木友保回顾了内皮素生物化学和分子生物学的现状。
