Sharmeen Saika, Kalkan Esra, Yi Chunhui, Smith Steven D
Department of Medicine, Mount Sinai St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.
Department of Pathology, Mount Sinai St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.
Case Rep Nephrol. 2016;2016:4186086. doi: 10.1155/2016/4186086. Epub 2016 Jan 19.
We report a case of acute kidney injury as the initial manifestation of sarcoidosis. A 55-year-old male was sent from his primary care physician's office with incidental lab findings significant for hypercalcemia and acute kidney injury with past medical history significant for nephrolithiasis. Initial treatment with intravenous hydration did not improve his condition. The renal biopsy subsequently revealed granulomatous interstitial nephritis (GIN). Treatment with the appropriate dose of glucocorticoids improved both the hypercalcemia and renal function. Our case demonstrates that renal limited GIN due to sarcoidosis, although a rare entity, can cause severe acute kidney injury and progressive renal failure unless promptly diagnosed and treated.
我们报告一例以急性肾损伤为结节病初始表现的病例。一名55岁男性从其初级保健医生办公室转诊而来，其偶然的实验室检查结果显示高钙血症和急性肾损伤，既往病史有肾结石。最初的静脉补液治疗未能改善其病情。随后的肾活检显示为肉芽肿性间质性肾炎（GIN）。使用适当剂量的糖皮质激素治疗改善了高钙血症和肾功能。我们的病例表明，结节病所致的肾脏局限性GIN虽然罕见，但可导致严重的急性肾损伤和进行性肾衰竭，除非及时诊断和治疗。
