Warshavsky Anton, Eilam Anda, Gilad Ronit
Neurology Department E. Wolfson Medical Center HolonIsrael; Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel.
Neurology Department Kaplan Medical Center Hebrew University of Jerusalem Rehovot Israel.
Brain Behav. 2016 Feb 10;6(3):e00419. doi: 10.1002/brb3.419. eCollection 2016 Mar.
OBJECTIVES/AIMS: The study was designed to evaluate the optimal dosage of lamotrigine, as monotherapy, in the treatment of adults suffering from complex partial seizures with or without secondary generalization in everyday clinical practice.
The ones used in this study was the collection of the data of all adult patients treated with lamotrigine, retrospectively. The dosage and efficacy of treatment were evaluated along with side effects and retention rate.
They showed that, out of 188 patients, 77% continued lamotrigine treatment; the mean effective dose was 250 mg or higher of lamotrigine, and the results more pronounced in older patients (age above 30 years) and those with a longer disease duration (5 years and more).
It may be appropriate to reach a daily lamotrigine dose above 250 mg in adult patients suffering from epilepsy for more than 5 years using lamotrigine as monotherapy.
本研究旨在评估在日常临床实践中，拉莫三嗪作为单一疗法治疗伴有或不伴有继发性全身性发作的复杂性部分性发作成人患者的最佳剂量。
本研究采用回顾性收集所有接受拉莫三嗪治疗的成年患者的数据。评估治疗的剂量、疗效以及副作用和保留率。
结果显示，在188例患者中，77%继续接受拉莫三嗪治疗；拉莫三嗪的平均有效剂量为250毫克或更高，且该结果在老年患者（30岁以上）和病程较长（5年及以上）的患者中更为明显。
对于使用拉莫三嗪作为单一疗法且癫痫病史超过5年的成年患者，将拉莫三嗪的每日剂量增至250毫克以上可能是合适的。
