Hejka A G, England D M, Schmitz J L, Schell R F
Wis Med J. 1989 Nov;88(11):17-20.
Lyme disease is a multisystem disease caused by the spirochete Borrelia burgdorferi and is transmitted to humans primarily through Ixodid ticks. The clinical spectrum of the disease is continuing to expand while in its wake the pathology and histopathologic manifestations are being uncovered. We review the pathology of Lyme disease in man beginning with the tick bite. We present the pathologic changes of the rash, erythema migrans, as well as the neurologic, cardiac, and arthritic changes of the disease. We can expand our understanding of the immunobiology of Lyme disease by studying the interactions of B. burgdorferi in an experimental animal model.
莱姆病是一种由伯氏疏螺旋体引起的多系统疾病，主要通过硬蜱传播给人类。该疾病的临床谱正在不断扩大，与此同时，其病理学和组织病理学表现也逐渐被揭示。我们从蜱叮咬开始回顾人类莱姆病的病理学。我们展示了皮疹（游走性红斑）的病理变化，以及该疾病的神经、心脏和关节变化。通过在实验动物模型中研究伯氏疏螺旋体的相互作用，我们可以扩展对莱姆病免疫生物学的理解。
