高密度脂蛋白（HDL）患者心脏风险（QRISK2）计算器的局限性
Limitations of a Cardiac Risk (QRISK2) Calculator in Patients with High Density Lipoprotein (HDL).
作者信息
Minhas Jatinder S, Patel Prashanth, Gupta Pankaj K
机构信息
Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Cardiovascular Biomedical Research Unit, Leicester, UK.
出版信息
High Blood Press Cardiovasc Prev. 2016 Mar;23(1):47-50. doi: 10.1007/s40292-016-0131-x. Epub 2016 Feb 23.
INTRODUCTION
There is existing debate as to the relationship between blood concentration of HDL (high density lipoprotein) and cardiovascular outcomes. Patients with hyperalphalipoproteinaemia (HALP) have high HDL levels and this can be attributed to a variety of factors.
AIM AND METHODS
This study aims for the first time to examine the HALP cohort and understand demographics, relationship with cardiovascular disease (CVD) risk and scoring with a cardiac risk calculator (QRISK 2 calculator).
RESULTS
The study found 42 patients had a statistically significant difference (p = 0.001) between CVD risk estimated using actual measured HDL (Score 1) versus CVD risk calculated using standard population mean HDL values (Score 2). Furthermore, in the CVD event group (n = 6) a significant difference was also seen between Score 1 and Score 2 (p = 0.027).
CONCLUSION
The study highlights issues with underestimation of CVD risk in this population and strongly advocates use of standard population mean values in assessment of CVD risk.
引言
关于高密度脂蛋白（HDL）血液浓度与心血管疾病转归之间的关系，目前存在争议。高α脂蛋白血症（HALP）患者的HDL水平较高，这可归因于多种因素。
目的与方法
本研究首次旨在对HALP队列进行研究，并了解其人口统计学特征、与心血管疾病（CVD）风险的关系以及使用心脏风险计算器（QRISK 2计算器）进行评分的情况。
结果
研究发现，42例患者使用实际测量的HDL估算的CVD风险（评分1）与使用标准人群平均HDL值计算的CVD风险（评分2）之间存在统计学显著差异（p = 0.001）。此外，在CVD事件组（n = 6）中，评分1和评分2之间也存在显著差异（p = 0.027）。
结论
该研究突出了该人群中CVD风险被低估的问题，并强烈主张在评估CVD风险时使用标准人群平均值。
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