Garin P, Frans A
Département de Médecine Internè, Cliniques Universitaires Saint-Luc (UCL), Bruxelles.
Acta Otorhinolaryngol Belg. 1989;43(2):131-9.
Some particular cases of bronchial asthma are improved by acetylsalicylic acid. The clinical characteristics of these patients are very similar to those of asthmatic ASA-sensitive cases: a cortico-dependent asthma occurring in later life, in nonatopic patients with chronic rhinitis, sinusitis and/or nasal polyposis. The patient notices that taking an occasional aspirin tablet for some other problem reduces his respiratory symptoms. The bronchodilator effect of aspirin and other Non Steroidal Anti-Inflammatory Drugs in such patients has been clearly demonstrated, although all drugs don't have the same effectiveness. It is important to diagnose these aspirin-relieved asthma cases, using an oral aspirin test, because the treatment with aspirin allows us then to reduce the needed corticosteroid dose. We hypothesize that a diversion of the arachidonic acid metabolism towards cyclo-oxygenase products causes this syndrome.
某些支气管哮喘的特殊病例可通过乙酰水杨酸得到改善。这些患者的临床特征与哮喘性阿司匹林敏感病例非常相似：一种发生于晚年、在非特应性慢性鼻炎、鼻窦炎和/或鼻息肉患者中的皮质激素依赖型哮喘。患者注意到因其他问题偶尔服用阿司匹林片会减轻其呼吸道症状。阿司匹林和其他非甾体抗炎药在此类患者中的支气管扩张作用已得到明确证实，尽管并非所有药物的效果都相同。通过口服阿司匹林试验诊断这些阿司匹林缓解型哮喘病例很重要，因为使用阿司匹林治疗可使我们随后减少所需的皮质类固醇剂量。我们推测花生四烯酸代谢转向环氧化酶产物会导致这种综合征。
