Fonberg E
Department of Neurophysiology, Nencki Institute of Experimental Biology, Poland.
Acta Physiol Hung. 1989;74(2):103-14.
The problem of the mechanisms of depression and action of the depressive drugs needs theoretical analysis and multichannel investigations. Animal models of depression are important for such investigations. Various neurochemical behavioral and psychological models were analysed in the present paper. Amygdalar model of depression seems to be one of the most important models. The effects of the treatment by amphetamine, imipramine and chlorpromazine on the amygdalar depressive syndrome in dogs were described. The individual differences were stressed, both in respect to forms of particular depression and to the sensitivity to drug treatment.
抑郁症的机制及抗抑郁药物的作用问题需要进行理论分析和多渠道研究。抑郁症动物模型对这类研究很重要。本文分析了各种神经化学、行为和心理模型。杏仁核抑郁症模型似乎是最重要的模型之一。描述了苯丙胺、丙咪嗪和氯丙嗪治疗对犬杏仁核抑郁综合征的影响。强调了个体差异，包括特定抑郁症的形式以及对药物治疗的敏感性。
