氯化锂在大鼠发育早期新生儿期的毒性作用。

Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development.

作者信息

Menshanov P N, Bannova A V, Dygalo N N

机构信息

Department of Physiology, Novosibirsk State University, Novosibirsk, Russia.

Department of Functional Neurogenomics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

出版信息

Bull Exp Biol Med. 2016 Feb;160(4):459-61. doi: 10.1007/s10517-016-3196-6. Epub 2016 Feb 24.

DOI:10.1007/s10517-016-3196-6

PMID:26906201

Abstract

Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.

摘要

将氯化锂（85、255或255 + 127微克/千克）或地塞米松（0.2或2毫克/千克）皮下注射到3日龄的幼鼠体内，这些幼鼠的排泄系统尚未达到功能成熟。这两种药物都延缓了幼鼠的生长，并推迟了负趋地性的出现。氯化锂的半数致死量和治疗指数分别为255微克/千克和TI≤3。因此，锂盐即使是低剂量也可能对发育中的生物体具有高毒性。