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将猿猴间充质干细胞移植到实验性诱导心肌梗死的狒狒体内。

Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction.

作者信息

Agrba V Z, Porkhanov V A, Karal-Ogly D D, Leontyuk A V, Kovalenko A L, Sholin I Yu, Gvozdik T E, Ignatova I E, Agumava A A, Chuguev Yu P, Gvaramiya I A, Lapin B A

机构信息

Research Institute of Medical Primatology, Sochi, Russia.

出版信息

Bull Exp Biol Med. 2016 Feb;160(4):589-91. doi: 10.1007/s10517-016-3223-7. Epub 2016 Feb 24.

DOI:10.1007/s10517-016-3223-7
PMID:26906203
Abstract

Culture of mesenchymal stem cells isolated from the bone marrow of primates by their characteristics met the requirements of stem cells. It was shown that transplantation of allogeneic mesenchymal stem cells (2 million cells per 1 kg body weight) immediately after ligation of the left anterior descending coronary artery between the middle and upper thirds led to neovascularization and capillarization of the ischemic myocardium.

摘要

从灵长类动物骨髓中分离出的间充质干细胞,经鉴定其特性符合干细胞要求。研究表明,在左前降支冠状动脉中上部三分之一处结扎后立即移植异体间充质干细胞(每1千克体重移植200万个细胞),可使缺血心肌实现新血管形成和毛细血管化。

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Transplantation of Simian Mesenchymal Stem Cells to Baboons with Experimentally Induced Myocardial Infarction.将猿猴间充质干细胞移植到实验性诱导心肌梗死的狒狒体内。
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