Dasdemir Selcuk, Kucukali Cem Ismail, Bireller Elif Sinem, Tuzun Erdem, Cakmakoglu Bedia
a Department of Molecular Medicine , Institute of Experimental Medicine, Istanbul University , Istanbul , Turkey ;
b Department of Neuroscience , Institute of Experimental Medicine, Istanbul University , Istanbul , Turkey.
Nord J Psychiatry. 2016 Aug;70(6):407-12. doi: 10.3109/08039488.2016.1141981. Epub 2016 Feb 23.
Background Chemokines are known to play a major role in driving inflammation and immune responses in several neuroinflammatory diseases, including multiple sclerosis, Alzheimer's disease and Parkinson's disease. Inflammation has also been implicated in the pathogenesis of schizophrenia. Aim We aimed to investigate a potential link between chemokines and schizophrenia and analyze the role of MCP-1-A2518G, SDF-1-3'A, CCR5-delta32, CCR5-A55029G, CXCR4-C138T and CCR2-V64I gene polymorphisms in the Turkish population. Methods Genotyping was conducted by PCR-RFLP based on 140 patients and 123 unrelated healthy controls to show the relation between chemokine gene variants and schizophrenia risk. Results Frequencies of CCR5-A55029G A genotypes and CCR5-A55029G AG genotypes were found higher in patients than the controls and even also CCR2-V64I WT: CCR5-A55029G A and CCR2-V64I 64I: CCR5-A55029G A haplotypes significantly associated according to Bonferroni correction. However, no significant association was found for any of the other polymorphisms with the risk of schizophrenia. Conclusions Our findings suggest that CCR5-A55029G polymorphisms and CCR2-V64I WT: CCR5-A55029G A and CCR2-V64I 64I: CCR5-A55029G A haplotypes might have association with schizophrenia pathogenesis.
背景 已知趋化因子在包括多发性硬化症、阿尔茨海默病和帕金森病在内的多种神经炎症性疾病中驱动炎症和免疫反应方面发挥着重要作用。炎症也与精神分裂症的发病机制有关。目的 我们旨在研究趋化因子与精神分裂症之间的潜在联系，并分析MCP-1-A2518G、SDF-1-3'A、CCR5-δ32、CCR5-A55029G、CXCR4-C138T和CCR2-V64I基因多态性在土耳其人群中的作用。方法 基于140例患者和123名无亲缘关系的健康对照进行聚合酶链反应-限制性片段长度多态性基因分型，以显示趋化因子基因变异与精神分裂症风险之间的关系。结果 发现患者中CCR5-A55029G A基因型和CCR5-A55029G AG基因型的频率高于对照组，甚至根据Bonferroni校正，CCR2-V64I WT:CCR5-A55029G A和CCR2-V64I 64I:CCR5-A55029G A单倍型也显著相关。然而，未发现其他任何多态性与精神分裂症风险有显著关联。结论 我们的研究结果表明，CCR5-A55029G多态性以及CCR2-V64I WT:CCR5-A55029G A和CCR2-V64I 64I:CCR5-A55029G A单倍型可能与精神分裂症的发病机制有关。
