McCarthy Patrick J, Zundel Hannah R, Johnson Kimberly R, Blohowiak Sharon E, Kling Pamela J
Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Meriter Hospital, Madison, WI.
J Pediatr Hematol Oncol. 2016 Apr;38(3):210-5. doi: 10.1097/MPH.0000000000000536.
To determine whether prenatal risk factors (RFs) that predict cord blood iron status in term newborns also predict iron status of premature newborns.
Cord blood iron indices from 80 preterm newborns were compared with historical and demographic RFs for developing iron deficiency if born at term.
The presence of multiple RFs did not incrementally interfere with cord iron status in preterm newborns. Poorer iron status accompanied being small for gestational age in prematurity, but other RFs, including diabetes, had relatively little impact.
Growth-restricted preterm newborns are at risk for poor iron endowment, likely due to uteroplacental insufficiency. Other RFs were less impactful on iron status of premature newborns than in term newborns, likely reflecting that disruptive effects of RFs are more impactful in the third trimester. Understanding RFs for poor iron endowment is important for clinical recognition and treatment of premature babies.
确定预测足月儿脐血铁状态的产前危险因素是否也能预测早产儿的铁状态。
将80例早产儿的脐血铁指标与足月出生时发生缺铁的历史和人口统计学危险因素进行比较。
多种危险因素的存在并未对早产儿的脐血铁状态产生渐进性干扰。早产时小于胎龄儿伴有较差的铁状态，但包括糖尿病在内的其他危险因素影响相对较小。
生长受限的早产儿有铁储备不足的风险，可能是由于子宫胎盘功能不全。其他危险因素对早产儿铁状态的影响小于足月儿，这可能反映出危险因素的干扰作用在孕晚期更为显著。了解铁储备不足的危险因素对于早产儿的临床识别和治疗很重要。
