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DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.DLK-1/p38丝裂原活化蛋白激酶信号通过调控秀丽隐杆线虫中RAB-5介导的内吞作用来控制纤毛长度。
PLoS Genet. 2015 Dec 11;11(12):e1005733. doi: 10.1371/journal.pgen.1005733. eCollection 2015 Dec.
2
Local and long-range activation of innate immunity by infection and damage in C. elegans.秀丽隐杆线虫中感染和损伤对先天免疫的局部和远距离激活
Curr Opin Immunol. 2016 Feb;38:1-7. doi: 10.1016/j.coi.2015.09.005. Epub 2015 Oct 28.
3
Axon Regeneration Is Regulated by Ets-C/EBP Transcription Complexes Generated by Activation of the cAMP/Ca2+ Signaling Pathways.轴突再生受cAMP/Ca2+信号通路激活所产生的Ets-C/EBP转录复合物调控。
PLoS Genet. 2015 Oct 20;11(10):e1005603. doi: 10.1371/journal.pgen.1005603. eCollection 2015 Oct.
4
Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.Toll样受体信号传导促进秀丽隐杆线虫病原体回避行为所需感觉神经元的发育和功能。
Curr Biol. 2015 Aug 31;25(17):2228-37. doi: 10.1016/j.cub.2015.07.037. Epub 2015 Aug 13.
5
Identification of new members of the MAPK gene family in plants shows diverse conserved domains and novel activation loop variants.植物中MAPK基因家族新成员的鉴定显示出不同的保守结构域和新的激活环变体。
BMC Genomics. 2015 Feb 6;16(1):58. doi: 10.1186/s12864-015-1244-7.
6
Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.轴突再生。埃坡霉素B的全身给药可促进脊髓损伤后的轴突再生。
Science. 2015 Apr 17;348(6232):347-52. doi: 10.1126/science.aaa2958. Epub 2015 Mar 12.
7
Tissue expression pattern of PMK-2 p38 MAPK is established by the miR-58 family in C. elegans.在秀丽隐杆线虫中，miR-58家族建立了PMK-2 p38丝裂原活化蛋白激酶的组织表达模式。
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8
Mechanical systems biology of C. elegans touch sensation.秀丽隐杆线虫触觉感受的机械系统生物学
Bioessays. 2015 Mar;37(3):335-44. doi: 10.1002/bies.201400154. Epub 2015 Jan 19.
9
Pathological axonal death through a MAPK cascade that triggers a local energy deficit.通过触发局部能量缺乏的丝裂原活化蛋白激酶级联反应导致的病理性轴突死亡。
Cell. 2015 Jan 15;160(1-2):161-76. doi: 10.1016/j.cell.2014.11.053.
10
Activation of a G protein-coupled receptor by its endogenous ligand triggers the innate immune response of Caenorhabditis elegans.内源性配体激活 G 蛋白偶联受体触发秀丽隐杆线虫的固有免疫反应。
Nat Immunol. 2014 Sep;15(9):833-8. doi: 10.1038/ni.2957. Epub 2014 Aug 3.

应激激活的丝裂原活化蛋白（MAP）激酶信号传导的背景特异性：秀丽隐杆线虫讲述的故事

Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told by Caenorhabditis elegans.

作者信息

Andrusiak Matthew G, Jin Yishi

机构信息

From the Howard Hughes Medical Institute and.

From the Howard Hughes Medical Institute and the Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093

出版信息

J Biol Chem. 2016 Apr 8;291(15):7796-804. doi: 10.1074/jbc.R115.711101. Epub 2016 Feb 23.

DOI:10.1074/jbc.R115.711101
PMID:26907690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4824986/
Abstract

Stress-associated p38 and JNK mitogen-activated protein (MAP) kinase signaling cascades trigger specific cellular responses and are involved in multiple disease states. At the root of MAP kinase signaling complexity is the differential use of common components on a context-specific basis. The roundwormCaenorhabditis eleganswas developed as a system to study genes required for development and nervous system function. The powerful genetics ofC. elegansin combination with molecular and cellular dissections has led to a greater understanding of how p38 and JNK signaling affects many biological processes under normal and stress conditions. This review focuses on the studies revealing context specificity of different stress-activated MAPK components inC. elegans.

摘要

应激相关的p38和JNK丝裂原活化蛋白（MAP）激酶信号级联反应触发特定的细胞反应，并参与多种疾病状态。MAP激酶信号复杂性的根源在于在特定背景下对共同成分的不同使用。线虫秀丽隐杆线虫被开发为一种研究发育和神经系统功能所需基因的系统。秀丽隐杆线虫强大的遗传学与分子和细胞剖析相结合，使人们对p38和JNK信号在正常和应激条件下如何影响许多生物学过程有了更深入的了解。本综述重点关注揭示秀丽隐杆线虫中不同应激激活的MAPK成分的背景特异性的研究。