应激激活的丝裂原活化蛋白（MAP）激酶信号传导的背景特异性：秀丽隐杆线虫讲述的故事
Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told by Caenorhabditis elegans.
作者信息
Andrusiak Matthew G, Jin Yishi
机构信息
From the Howard Hughes Medical Institute and.
From the Howard Hughes Medical Institute and the Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093
出版信息
J Biol Chem. 2016 Apr 8;291(15):7796-804. doi: 10.1074/jbc.R115.711101. Epub 2016 Feb 23.
Abstract
Stress-associated p38 and JNK mitogen-activated protein (MAP) kinase signaling cascades trigger specific cellular responses and are involved in multiple disease states. At the root of MAP kinase signaling complexity is the differential use of common components on a context-specific basis. The roundwormCaenorhabditis eleganswas developed as a system to study genes required for development and nervous system function. The powerful genetics ofC. elegansin combination with molecular and cellular dissections has led to a greater understanding of how p38 and JNK signaling affects many biological processes under normal and stress conditions. This review focuses on the studies revealing context specificity of different stress-activated MAPK components inC. elegans.
摘要
应激相关的p38和JNK丝裂原活化蛋白（MAP）激酶信号级联反应触发特定的细胞反应，并参与多种疾病状态。MAP激酶信号复杂性的根源在于在特定背景下对共同成分的不同使用。线虫秀丽隐杆线虫被开发为一种研究发育和神经系统功能所需基因的系统。秀丽隐杆线虫强大的遗传学与分子和细胞剖析相结合，使人们对p38和JNK信号在正常和应激条件下如何影响许多生物学过程有了更深入的了解。本综述重点关注揭示秀丽隐杆线虫中不同应激激活的MAPK成分的背景特异性的研究。
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