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核激素受体对 microRNAs 的调控控制线虫固有免疫反应。

Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.

机构信息

Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai, China.

出版信息

PLoS Pathog. 2013;9(8):e1003545. doi: 10.1371/journal.ppat.1003545. Epub 2013 Aug 22.

DOI:10.1371/journal.ppat.1003545
PMID:23990780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3749966/
Abstract

Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.

摘要

核激素受体对小分子（如视黄酸或类固醇）作出反应，并调节发育。保守的 p38/PMK-1 MAP 激酶途径的信号转导调节先天免疫。在这项研究中，我们表明，秀丽隐杆线虫核受体 DAF-12 通过下游的 let-7 微 RNA 家族负调控对病原体的防御，该家族直接靶向 PMK-1 下游的基因 SKN-1。这些发现确定了核激素受体作为先天免疫的组成部分，与 p38/PMK-1 MAP 激酶途径相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/8dcf8b7a4252/ppat.1003545.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/7d1ff42c8193/ppat.1003545.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/a224c89207c5/ppat.1003545.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/cbb034a2b9c1/ppat.1003545.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/2ec3a2c4b681/ppat.1003545.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/701b52a381e0/ppat.1003545.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/761781524f83/ppat.1003545.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/8dcf8b7a4252/ppat.1003545.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/7d1ff42c8193/ppat.1003545.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/a224c89207c5/ppat.1003545.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/cbb034a2b9c1/ppat.1003545.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/2ec3a2c4b681/ppat.1003545.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/701b52a381e0/ppat.1003545.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/761781524f83/ppat.1003545.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f16/3749966/8dcf8b7a4252/ppat.1003545.g007.jpg

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