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[灯刷染色体的研究进展及其在遗传学教学中应用的若干建议]

[Research progress in lampbrush chromosomes and some suggestions for their use in genetics teaching].

作者信息

Chen Fan-guo, Li Qing-qing

机构信息

1. Genetic Teaching and Research Group, School of Life Science, Shandong University, Jinan 250100, China; 2. The Key Laboratory of Plant Cell Engineering and Germplasm Innovation, Ministry of Education, School of Life Science, Shandong University, Jinan 250100, China;

The Key Laboratory of Plant Cell Engineering and Germplasm Innovation, Ministry of Education, School of Life Science, Shandong University, Jinan 250100, China.

出版信息

Yi Chuan. 2016 Feb;38(2):170-7. doi: 10.16288/j.yczz.15-417.

Abstract

Lampbrush chromosomes (LBCs) are transient giant transcripts that exist at the diplotene stage of the first meiotic division in female gametocytes of almost all animals except mammals. LBCs are named for their lampbrush-like structure, however, they received the lowest research attention in studies of three classical cytogenetic chromosomes. They have been excellent models for studying the structure, organization, transcription, and transcriptional processing of chromosomes during meiosis. Here we briefly summarized these studies and LBCs forming mechanism and also discussed their possible functions, such as providing enough transcriptional products for embryonic development by oocytes LBCs or polyploidy demonstrated by previous reports. Finally, we discussed the possibility of introducing this typical case into our genetics teaching to inspire students' interest in genetics.

摘要

灯刷染色体(LBCs)是一种短暂存在的巨大转录物,存在于除哺乳动物外几乎所有动物的雌性配子细胞第一次减数分裂的双线期。灯刷染色体因其类似灯刷的结构而得名,然而,在三种经典细胞遗传学染色体的研究中,它们受到的研究关注最少。它们一直是研究减数分裂过程中染色体的结构、组织、转录和转录加工的优秀模型。在此,我们简要总结了这些研究以及灯刷染色体的形成机制,并讨论了它们可能的功能,例如卵母细胞的灯刷染色体为胚胎发育提供足够的转录产物,或者如先前报道所示的多倍体现象。最后,我们讨论了将这个典型案例引入遗传学教学以激发学生对遗传学兴趣的可能性。

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