Kobayashi Satoru, Karube Yoko, Nishihira Morimichi, Inoue Takashi, Araki Osamu, Sado Tetsu, Chida Masayuki
Department of General Thoracic Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Japan.
World J Surg. 2016 Jul;40(7):1632-7. doi: 10.1007/s00268-016-3459-4.
There is increasing evidence that Glasgow Prognostic Score (GPS), based on systemic inflammatory response and albumin level, is a useful predictor of overall survival in patients with various types of cancer.
Patients with lung metastasis from colorectal carcinoma who underwent a lung metastasectomy from 2000 to 2015 were retrospectively investigated. Routine laboratory measurements including serum C-reactive protein (CRP), albumin, and the tumor marker carcinoembryonic antigen were performed before the metastasectomy.
Ninety-nine patients underwent 132 lung metastasectomy procedures during the study period. Kaplan-Meier analysis revealed that GPS (p = 0.017), number of metastases (p = 0.004), and the presence of liver metastasis (p = 0.010) were associated with overall survival, while univariate analysis selected GPS (p = 0.028), number of metastases (p = 0.005), and liver metastasis (p = 0.014) as predictive factors associated with overall survival. Multivariate analysis also indicated GPS (p = 0.004), number of metastases (p = 0.004), and liver metastasis (p = 0.013) as predictive factors associated with overall survival.
In addition to number of metastases and liver metastasis, GPS is an important predictor of overall survival in colorectal cancer patients who undergo a lung metastasectomy.
越来越多的证据表明，基于全身炎症反应和白蛋白水平的格拉斯哥预后评分（GPS）是各类癌症患者总生存期的有效预测指标。
对2000年至2015年间接受肺转移瘤切除术的结直肠癌肺转移患者进行回顾性研究。在转移瘤切除术前进行常规实验室检测，包括血清C反应蛋白（CRP）、白蛋白和肿瘤标志物癌胚抗原。
在研究期间，99例患者接受了132次肺转移瘤切除手术。Kaplan-Meier分析显示，GPS（p = 0.017）、转移灶数量（p = 0.004）和肝转移的存在（p = 0.010）与总生存期相关，而单因素分析选择GPS（p = 0.028）、转移灶数量（p = 0.005）和肝转移（p = 0.014）作为与总生存期相关的预测因素。多因素分析也表明GPS（p = 0.004）、转移灶数量（p = 0.004）和肝转移（p = 0.013）是与总生存期相关的预测因素。
除转移灶数量和肝转移外，GPS是接受肺转移瘤切除术的结直肠癌患者总生存期的重要预测指标。
