McGhee William, Michaels Marian G, Martin Judith M, Mazariegos George V, Green Michael
Department of Pharmacy, Children's Hospital of Pittsburgh Department of Pharmacy and Therapeutics, University of Pittsburgh Pharmacy School.
Department of Infectious Diseases, Children's Hospital of Pittsburgh Department of Infectious Diseases, University of Pittsburgh Medical School.
J Pediatric Infect Dis Soc. 2016 Mar;5(1):80-4. doi: 10.1093/jpids/piu083. Epub 2014 Aug 14.
We conducted a prospective pilot study to evaluate the potential role of combined systemic antifungal and liposomal amphotericin B lock therapy in children with intestinal insufficiency with fungal catheter-related bloodstream infections whose central venous catheters had not been removed. Our results provide supportive evidence for the conduct of larger clinical trials to confirm the efficacy and safety of this approach.
我们进行了一项前瞻性试点研究，以评估全身抗真菌药物联合脂质体两性霉素B封管疗法在患有真菌导管相关血流感染且未拔除中心静脉导管的肠道功能不全儿童中的潜在作用。我们的结果为开展更大规模的临床试验以证实该方法的有效性和安全性提供了支持性证据。
