Imbert Christine, Rammaert Blandine
Laboratory of Ecology and Biology of Interactions, University of Poitiers, UMR CNRS 7267, F-86073 Poitiers, France.
Faculty of Medicine and Pharmacy, University of Poitiers, F-86073 Poitiers, France.
Pathogens. 2018 Jan 6;7(1):6. doi: 10.3390/pathogens7010006.
Candidemia related to the presence of a biofilm are often reported in patients with vascular catheters. Once they are mature, biofilms are persistent infectious reservoirs, and the yeasts dispersed from biofilms can cause infections. Sessile yeasts typically display increased levels of resistance to most antimicrobial agents and systemic treatments usually fail to eradicate previously formed fungal biofilms. In a curative strategy, antifungal lock therapy may help to sterilize catheters, with very high concentrations of antifungal agents, which are not compatible with systemic use. This strategy has been studied by several authors in in vitro and in vivo studies, and more rarely, in clinical settings for adult and paediatric patients. Our study aims to assess the efficacy of the antifungal solutions used for lock therapy and demonstrated by the different teams.
与生物膜存在相关的念珠菌血症在血管导管患者中经常有报道。生物膜一旦成熟，就是持续存在的感染源，从生物膜中分散出来的酵母可引发感染。固着型酵母通常对大多数抗菌药物的耐药性增强，全身治疗通常无法根除先前形成的真菌生物膜。在一种治疗策略中，抗真菌封管疗法可能有助于通过使用浓度极高、与全身用药不相容的抗真菌药物来使导管无菌。几位作者已在体外和体内研究中对该策略进行了研究，在成人和儿科患者的临床环境中进行的研究则较少。我们的研究旨在评估不同团队所采用的用于封管疗法的抗真菌溶液的疗效。
