A 1-Year-Old with Mycobacterium tuberculosis Endocarditis with Mass Spectrometry Analysis of Cardiac Vegetation Composition.

作者信息

Sass Laura A, Ziemba Keegan J, Heiser Elizabeth A, Mauriello Clifford T, Werner Alice L, Aguiar Maria A, Nyalwidhe Julius O, Cunnion Kenji M

机构信息

The Departments of Pediatrics The Children's Hospital of The King's Daughters, Norfolk, Virginia Children's Specialty Group, Norfolk, Virginia.

The Departments of Pediatrics.

出版信息

J Pediatric Infect Dis Soc. 2016 Mar;5(1):85-8. doi: 10.1093/jpids/piu087. Epub 2014 Aug 27.

In this study, we report the first case of Mycobacterium tuberculosis endocarditis in an immunocompetent child born in the United States. Mass spectrometry of the vegetation identified coagulation, humoral immune proteins, neutrophil granule proteins, and histones. Few neutrophils on histopathology suggest that neutrophil extracellular traps may contribute to tuberculous endocardiac mass formation.