Farhood Zachary, Zhan Kevin Y, Lentsch Eric J
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Otolaryngol Head Neck Surg. 2016 May;154(5):875-9. doi: 10.1177/0194599816630546. Epub 2016 Feb 23.
To describe the clinical, demographic, and prognostic features of salivary gland mucinous adenocarcinoma, a rare head and neck malignancy.
Population-based national cancer registry analysis.
Academic medical center.
A review was performed with the National Cancer Database from 1998 to 2012. Demographic, clinical, and survival characteristics were compiled and analyzed. Cox multivariate regression was used to identify predictors of survival. Log-rank tests were used to test survival differences unless otherwise specified.
A total of 170 cases were identified. The most common site of involvement was the parotid gland. Rates of nodal and distant metastases were 45.9% and 10.6%, respectively. High histologic grade was associated with nodal disease (P < .001) and advanced-stage disease (P = .006). Overall 5- and 10-year survival rates were 60% and 44%, respectively. Multivariate analysis found tumor size ≥2 cm (hazard ratio, 22.6; 95% confidence interval: 4.06-126.09; P < .001) and distant metastases (hazard ratio, 17.6; 95% confidence interval: 3.75-82.68; P < .001) to predict poor outcomes.
Mucinous adenocarcinoma of the salivary gland is a rare otolaryngic cancer. Regional metastases and advanced stage are more common with high histologic grade. Tumor size and distant metastases negatively influence survival.
描述涎腺黏液腺癌这一罕见的头颈部恶性肿瘤的临床、人口统计学和预后特征。
基于人群的国家癌症登记分析。
学术医疗中心。
对1998年至2012年的国家癌症数据库进行回顾。收集并分析人口统计学、临床和生存特征。采用Cox多因素回归分析确定生存预测因素。除非另有说明，采用对数秩检验来检验生存差异。
共识别出170例病例。最常受累部位是腮腺。区域淋巴结转移率和远处转移率分别为45.9%和10.6%。高组织学分级与区域淋巴结疾病（P <.001）和晚期疾病（P =.006）相关。总体5年和10年生存率分别为60%和44%。多因素分析发现肿瘤大小≥2 cm（风险比，22.6；95%置信区间：4.06 - 126.09；P <.001）和远处转移（风险比，17.6；95%置信区间：3.75 - 82.68；P <.001）可预测不良预后。
涎腺黏液腺癌是一种罕见的耳鼻喉科癌症。高组织学分级时区域转移和晚期更为常见。肿瘤大小和远处转移对生存有负面影响。
