Departments of Pediatrics, and.
Departments of Pediatrics, and
Pediatrics. 2016 Mar;137(3):e20153369. doi: 10.1542/peds.2015-3369. Epub 2016 Feb 2.
Delirium is increasingly recognized as a common syndrome in critically ill children, but in our experience, it is rarely considered in the NICU. Delirium is independently associated with prolonged length of stay and adverse long-term outcomes in children. We report the cases of 3 infants cared for in our NICU at corrected gestational ages of 4, 11, and 17 weeks who presented with classic symptoms of delirium. All 3 children had complex medical problems and were receiving multiple analgesic and sedative medications. All 3 children exhibited agitation that was unresponsive to increasing doses of medications, and they all appeared to improve after treatment with quetiapine, allowing weaning of other medications. It is possible that with increased vigilance, delirium will be increasingly recognized in newborns, thus allowing tailored intervention. Further research is needed to investigate the prevalence and associated risk factors for developing delirium in the NICU and to explore possible treatment options.
谵妄越来越被认为是危重症儿童的一种常见综合征，但根据我们的经验，在新生儿重症监护病房（NICU）中很少考虑到这一点。谵妄与儿童住院时间延长和不良长期结局独立相关。我们报告了在我们的 NICU 中接受治疗的 3 名婴儿的病例，他们的校正胎龄分别为 4 周、11 周和 17 周，表现出典型的谵妄症状。这 3 名儿童都有复杂的医疗问题，并接受了多种镇痛和镇静药物治疗。所有 3 名儿童都表现出对增加剂量的药物无反应的躁动，并且在使用喹硫平治疗后都有所改善，从而能够减少其他药物的使用。随着警惕性的提高，新生儿谵妄的识别可能会越来越多，从而可以进行针对性的干预。需要进一步研究以调查 NICU 中发生谵妄的患病率和相关风险因素，并探讨可能的治疗选择。
