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运动与生长激素疗法相结合：我们如何从动物模型转化应用于慢性肾脏病儿童？

Combining exercise and growth hormone therapy: how can we translate from animal models to chronic kidney disease children?

作者信息

Bacchetta Justine, Salusky Isidro B

机构信息

Centre de Référence des Maladies Rénales Rares, Service de Néphrologie Rhumatologie Dermatologie Pédiatriques, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677 Bron Cedex, France INSERM 1033, Lyon, France Faculté de Médecine Lyon Est, Université de Lyon, Lyon, France.

David Geffen School of Medicine at UCLA, Division of Pediatric Nephrology, Los Angeles, CA, USA.

出版信息

Nephrol Dial Transplant. 2016 Aug;31(8):1191-4. doi: 10.1093/ndt/gfv461. Epub 2016 Jan 31.

DOI:10.1093/ndt/gfv461
PMID:26908776
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6296323/
Abstract

…Exercise and rhGH: a win/win combination for bone, growth … and maybe the vasculature system later in life?

摘要

运动与重组人生长激素

对骨骼、生长……以及或许对日后的血管系统而言是双赢组合？

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Combining exercise and growth hormone therapy: how can we translate from animal models to chronic kidney disease children?运动与生长激素疗法相结合：我们如何从动物模型转化应用于慢性肾脏病儿童？
Nephrol Dial Transplant. 2016 Aug;31(8):1191-4. doi: 10.1093/ndt/gfv461. Epub 2016 Jan 31.
2
Growth hormone therapy in children with CKD after more than two decades of practice.二十多年实践后儿童慢性肾脏病的生长激素治疗
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Growth, chronic kidney disease and pediatric kidney transplantation: is it useful to use recombinant growth hormone in Colombian children with renal transplant?生长、慢性肾脏病与小儿肾移植：重组生长激素对哥伦比亚肾移植儿童是否有用？
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Can provocative growth hormone testing predict the response to recombinant human growth hormone (rhGH) treatment?激发生长激素检测能否预测对重组人生长激素（rhGH）治疗的反应？
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Growth retardation in children with chronic renal insufficiency.慢性肾功能不全患儿的生长发育迟缓
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[Treatment of growth retardation in children with renal insufficiency using biosynthetic human growth hormone].[使用生物合成人生长激素治疗肾功能不全儿童的生长迟缓]
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Growth hormone treatment of short children with chronic renal failure before and after renal transplantation: rationale and recent results.慢性肾功能衰竭患儿肾移植前后生长激素治疗：理论依据及近期结果
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Effect of growth hormone treatment on the adult height of children with chronic renal failure. German Study Group for Growth Hormone Treatment in Chronic Renal Failure.生长激素治疗对慢性肾衰竭儿童成年身高的影响。德国慢性肾衰竭生长激素治疗研究组。
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Growth hormone treatment in children before and after renal transplantation.肾移植前后儿童的生长激素治疗
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Pediatr Nephrol. 2021 Jul;36(7):1861-1870. doi: 10.1007/s00467-021-04918-y. Epub 2021 Feb 17.

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Endurance exercise and growth hormone improve bone formation in young and growth-retarded chronic kidney disease rats.耐力运动和生长激素可改善年轻和生长迟缓的慢性肾脏病大鼠的骨形成。
Nephrol Dial Transplant. 2016 Aug;31(8):1270-9. doi: 10.1093/ndt/gfv373. Epub 2015 Nov 10.
2
The role of exercise training in the management of chronic kidney disease.运动训练在慢性肾脏病管理中的作用。
Curr Opin Nephrol Hypertens. 2015 Nov;24(6):480-7. doi: 10.1097/MNH.0000000000000165.
3
Pubertal growth and epiphyseal fusion.青春期生长与骨骺融合。
Ann Pediatr Endocrinol Metab. 2015 Mar;20(1):8-12. doi: 10.6065/apem.2015.20.1.8. Epub 2015 Mar 31.
4
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation.通往骨骼的途径：参与软骨细胞发育和成熟的信号分子及转录因子
Development. 2015 Mar 1;142(5):817-31. doi: 10.1242/dev.105536.
5
Exercise training in CKD: efficacy, adherence, and safety.慢性肾脏病患者的运动训练：疗效、依从性和安全性。
Am J Kidney Dis. 2015 Apr;65(4):583-91. doi: 10.1053/j.ajkd.2014.09.017. Epub 2014 Nov 14.
6
Optimizing bone health in children and adolescents.优化儿童和青少年的骨骼健康。
Pediatrics. 2014 Oct;134(4):e1229-43. doi: 10.1542/peds.2014-2173.
7
Use of pedometers to increase physical activity among children and adolescents with chronic kidney disease.使用计步器增加慢性肾病儿童和青少年的身体活动量。
Pediatr Nephrol. 2014 Aug;29(8):1395-402. doi: 10.1007/s00467-014-2787-6. Epub 2014 Mar 20.
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Exercise to improve pediatric bone and fat: a systematic review and meta-analysis.运动对改善儿童骨骼和脂肪的影响：系统评价和荟萃分析。
Med Sci Sports Exerc. 2014 Mar;46(3):610-21. doi: 10.1249/MSS.0b013e3182a6ab0d.
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Epiphyseal growth plate growth hormone receptor signaling is decreased in chronic kidney disease-related growth retardation.慢性肾脏病相关生长迟缓患者的骺板生长激素受体信号转导降低。
Kidney Int. 2013 Nov;84(5):940-9. doi: 10.1038/ki.2013.196. Epub 2013 May 29.
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The skeletal consequences of growth hormone therapy in dialyzed children: a randomized trial.生长激素治疗对透析患儿骨骼的影响：一项随机试验。
Clin J Am Soc Nephrol. 2013 May;8(5):824-32. doi: 10.2215/CJN.00330112. Epub 2013 Apr 4.