Akber Aalia, Portale Anthony A, Johansen Kirsten L
Department of Pediatrics, Division of Nephrology, Kaiser Oakland Medical Center, Oakland, CA, USA.
Pediatr Nephrol. 2014 Aug;29(8):1395-402. doi: 10.1007/s00467-014-2787-6. Epub 2014 Mar 20.
Children and adolescents with chronic kidney disease (CKD) are inactive relative to their peers.
Forty-four children and adolescents aged 7-20 years with CKD, end-stage renal disease (ESRD) on dialysis or a kidney transplant participated in a 12-week pedometer-based intervention to increase physical activity. Patients recorded daily step counts and reported them weekly. Pediatric Quality of Life Inventory (PedsQL) and 6-min walk (6 MW) were administered at baseline and after 12 weeks.
Age was 15.1 ± 3.4 years; 27 % had CKD, 16 % were receiving dialysis, and 57 % had received a kidney transplant. Mean daily step count did not change significantly (+48, 95 % CI -48 to +145 steps/day per week). Transplant recipients and patients with CKD increased their activity by 100 steps/day (95 % CI -14 to 208) and 73 steps/day (95 % CI -115 to 262) each week, respectively, and patients on dialysis decreased by 133 steps/day (95 % CI -325 to 58; p value for interaction 0.03) in multivariable analysis. Change in physical activity was associated with change in 6 MW distance (r = 0.74, p < 0.001) and change in physical functioning (r = 0.53, p = 0.001).
Youths with CKD did not significantly increase their activity over 12 weeks of a pedometer-based intervention. However, changes in physical activity were associated with changes in physical functioning and performance.
患有慢性肾脏病（CKD）的儿童和青少年相对于同龄人活动较少。
44名年龄在7至20岁之间患有CKD、接受透析的终末期肾病（ESRD）或接受肾移植的儿童和青少年参与了一项为期12周的基于计步器的干预措施，以增加身体活动。患者记录每日步数并每周汇报。在基线和12周后进行儿童生活质量量表（PedsQL）和6分钟步行试验（6MW）。
年龄为15.1±3.4岁；27%患有CKD，16%正在接受透析，57%接受了肾移植。平均每日步数没有显著变化（每周增加48步，95%置信区间为-48至+145步/天）。在多变量分析中，肾移植受者和CKD患者每周分别增加活动量100步/天（95%置信区间为-14至208）和73步/天（95%置信区间为-115至262），而透析患者则减少133步/天（95%置信区间为-325至58；交互作用p值为0.03）。身体活动的变化与6MW距离的变化（r = 0.74，p < 0.001）和身体功能的变化（r = 0.53，p = 0.001）相关。
患有CKD的青少年在基于计步器的12周干预中活动量没有显著增加。然而，身体活动的变化与身体功能和表现的变化相关。
