Smeekens S P, van de Veerdonk F L, Netea M G
Internal Medicine, Radboud University Medical Center Nijmegen, Netherlands.
Front Microbiol. 2016 Feb 16;7:154. doi: 10.3389/fmicb.2016.00154. eCollection 2016.
Candida species can cause severe infections associated with high morbidity and mortality. Therefore, it is essential to gain more insight into the anti-fungal host defense response. The advent of omics technology and development of advanced systems biology tools has permitted to approach this in an unbiased and quantitative manner. This review summarizes the insights gained on anti-Candida immunity from genetic-, transcriptome-, proteome-, metabolome-, microbiome-, mycobiome-, and computational systems biology studies and discusses practical aspects and future perspectives.
念珠菌属可引起与高发病率和死亡率相关的严重感染。因此，深入了解抗真菌宿主防御反应至关重要。组学技术的出现和先进系统生物学工具的发展使得能够以无偏见和定量的方式来研究这一问题。本综述总结了从遗传、转录组、蛋白质组、代谢组、微生物组、真菌组和计算系统生物学研究中获得的关于抗念珠菌免疫的见解，并讨论了实际应用方面和未来前景。
