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放射性药物在胰腺癌治疗与诊断中的进展。

Advancement in treatment and diagnosis of pancreatic cancer with radiopharmaceuticals.

作者信息

Xu Yu-Ping, Yang Min

机构信息

Yu-Ping Xu, Min Yang, Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, Jiangsu Province, China.

出版信息

World J Gastrointest Oncol. 2016 Feb 15;8(2):165-72. doi: 10.4251/wjgo.v8.i2.165.

DOI:10.4251/wjgo.v8.i2.165
PMID:26909131
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4753167/
Abstract

Pancreatic cancer (PC) is a major health problem. Conventional imaging modalities show limited accuracy for reliable assessment of the tumor. Recent researches suggest that molecular imaging techniques with tracers provide more biologically relevant information and are benefit for the diagnosis of the cancer. In addition, radiopharmaceuticals also play more important roles in treatment of the disease. This review summaries the advancement of the radiolabeled compounds in the theranostics of PC.

摘要

胰腺癌(PC)是一个重大的健康问题。传统成像方式在可靠评估肿瘤方面准确性有限。最近的研究表明,带有示踪剂的分子成像技术能提供更多生物学相关信息,有利于癌症的诊断。此外,放射性药物在该疾病的治疗中也发挥着更重要的作用。这篇综述总结了放射性标记化合物在胰腺癌诊疗中的进展。

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本文引用的文献

1
F-18 fluorodeoxyglucose positron emission tomography for differential diagnosis of pancreatic tumors.F-18氟脱氧葡萄糖正电子发射断层扫描在胰腺肿瘤鉴别诊断中的应用
Springerplus. 2015 Mar 31;4:154. doi: 10.1186/s40064-015-0938-2. eCollection 2015.
2
Recent developments in imaging of pancreatic neuroendocrine tumors.胰腺神经内分泌肿瘤成像的最新进展。
Ann Gastroenterol. 2015 Apr-Jun;28(2):193-202.
3
Molecular imaging in the era of personalized medicine.个性化医疗时代的分子成像
J Pathol Transl Med. 2015 Jan;49(1):5-12. doi: 10.4132/jptm.2014.10.24. Epub 2015 Jan 15.
4
Preliminary evaluation of [18F]AlF-NOTA-MAL-Cys39-exendin-4 in insulinoma with PET.[18F]AlF-NOTA-MAL-Cys39-艾塞那肽-4在胰岛素瘤中的PET初步评估。
J Drug Target. 2015;23(9):813-20. doi: 10.3109/1061186X.2015.1020808. Epub 2015 Mar 11.
5
Advanced pancreatic adenocarcinoma: a review of current treatment strategies and developing therapies.晚期胰腺腺癌:当前治疗策略和新兴疗法的综述。
Ther Adv Med Oncol. 2015 Mar;7(2):68-84. doi: 10.1177/1758834014564775.
6
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