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石棉暴露后小鼠肺部铁和钙的组织病理学数据。

Histopathological data of iron and calcium in the mouse lung after asbestos exposure.

作者信息

Trevisan Elisa, Zabucchi Giuliano, Pascolo Lorella, Pascotto Ernesto, Casarsa Claudia, Lucattelli Monica, Lungarella Giuseppe, Cavarra Eleonora, Bartalesi Barbara, Zweyer Marina, Borelli Violetta

机构信息

Department of Life Science, University of Trieste, 34127 Trieste, Italy.

Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34137 Trieste, Italy.

出版信息

Data Brief. 2016 Jan 21;6:769-75. doi: 10.1016/j.dib.2016.01.026. eCollection 2016 Mar.

DOI:10.1016/j.dib.2016.01.026
PMID:26909387
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4744238/
Abstract

This data article contains data related to the research article entitled, "Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice" [1]. Asbestos fibers disrupt iron homeostasis in the human and mouse lung, leading to the deposition of iron (Fe) onto longer asbestos fibers which forms asbestos bodies (AB) [2]. Similar to Fe, calcium (Ca) is also deposited in the coats of the AB. This article presents data on iron and calcium in the mouse lung after asbestos exposure detected by histochemical evaluation.

摘要

本数据文章包含与题为《同步辐射X射线显微镜揭示暴露小鼠肺中钙和铁与青石棉纤维的早期相互作用》的研究文章相关的数据[1]。石棉纤维会破坏人和小鼠肺中的铁稳态,导致铁(Fe)沉积在较长的石棉纤维上,形成石棉小体(AB)[2]。与铁类似,钙(Ca)也沉积在石棉小体的包膜中。本文展示了通过组织化学评估检测到的石棉暴露后小鼠肺中铁和钙的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/95f5766e7918/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/bd60c8debca4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/f17d6c07e335/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/3aebadbb849d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/95f5766e7918/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/bd60c8debca4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/f17d6c07e335/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/3aebadbb849d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5c/4744238/95f5766e7918/gr4.jpg

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本文引用的文献

1
Synchrotron X-ray microscopy reveals early calcium and iron interaction with crocidolite fibers in the lung of exposed mice.同步加速器X射线显微镜揭示了暴露小鼠肺部中早期钙和铁与青石棉纤维的相互作用。
Toxicol Lett. 2016 Jan 22;241:111-20. doi: 10.1016/j.toxlet.2015.11.016. Epub 2015 Nov 18.
2
α-Lipoic acid attenuates coxsackievirus B3-induced ectopic calcification in heart, pancreas, and lung.α-硫辛酸可减轻柯萨奇病毒 B3 诱导的心脏、胰腺和肺的异位钙化。
Biochem Biophys Res Commun. 2013 Mar 8;432(2):378-83. doi: 10.1016/j.bbrc.2013.01.061. Epub 2013 Jan 26.
3
Iron homeostasis in the lung following asbestos exposure.
石棉暴露后肺内的铁稳态。
Antioxid Redox Signal. 2008 Feb;10(2):371-7. doi: 10.1089/ars.2007.1909.
4
Susceptibility to asbestos-induced and transforming growth factor-beta1-induced fibroproliferative lung disease in two strains of mice.两种品系小鼠对石棉诱导和转化生长因子-β1诱导的纤维增生性肺病的易感性。
Am J Respir Cell Mol Biol. 2002 Dec;27(6):705-13. doi: 10.1165/rcmb.2002-0096OC.
5
Response of mouse lung to crocidolite asbestos. 2. Pulmonary fibrosis after long fibres.小鼠肺对青石棉的反应。2. 长期接触长纤维后的肺纤维化
J Pathol. 1987 Jun;152(2):109-17. doi: 10.1002/path.1711520207.