2型糖尿病患者空腹过夜后血清脂联素和内脂素水平的相互变化。
Reciprocal changes of serum adispin and visfatin levels in patients with type 2 diabetes after an overnight fast.
作者信息
Legakis Ioannis, Mantzouridis Timos, Bouboulis George, Chrousos George P
机构信息
Iaso General Hospital, Athens, Greece.
Euromedica High Technology S.A, Athens, Greece.
出版信息
Arch Endocrinol Metab. 2016 Feb;60(1):76-8. doi: 10.1590/2359-3997000000147.
Abstract
OBJECTIVE
In order to elucidate the interrelationship of adipokines in glucose hemiostasis, we determined the concentration of visfatin and adipsin in blood samples in patients with type 2 diabetes and age-matched controls after an overnight fast.
SUBJECTS AND METHODS
We enrolled 37 patients with known type 2 diabetes -21 males and 16 females, aged 62.95 ± 15.72 years and 43 controls- 28 males and 15 females, aged 60.79 ± 12.67 years. Blood samples were collected after an overnight fast and routine biochemical parameters such as glucose, cholesterol, HDL, LDL, triglycerides along with Hb1Ac, insulin and c-peptide, in addition to circulating visfatin and adipsin were determined in all samples. Data were considered significant at a level of p < 0.05.
RESULTS
In patients with type 2 diabetes, circulating adipsin levels were decreased and inversely related with glucose levels while circulating visfatin was increased significantly in the fasting state.
CONCLUSION
These results implicate the adipokines adipsin and visfatin as possible participants in the pathogenesis of type 2 diabetes.
摘要
目的
为阐明脂肪因子在葡萄糖稳态中的相互关系，我们测定了2型糖尿病患者和年龄匹配的对照者空腹过夜后血样中内脂素和脂肪酶的浓度。
对象与方法
我们纳入了37例已知2型糖尿病患者（21例男性和16例女性，年龄62.95±15.72岁）和43例对照者（28例男性和15例女性，年龄60.79±12.67岁）。空腹过夜后采集血样，测定所有样本中的常规生化参数，如葡萄糖、胆固醇、高密度脂蛋白、低密度脂蛋白、甘油三酯以及糖化血红蛋白、胰岛素和C肽，此外还测定循环内脂素和脂肪酶。数据在p<0.05水平被认为具有显著性。
结果
在2型糖尿病患者中，循环脂肪酶水平降低且与血糖水平呈负相关，而空腹状态下循环内脂素显著升高。
结论
这些结果表明脂肪因子脂肪酶和内脂素可能参与了2型糖尿病的发病机制。
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