Jerusha Faith R, Raghunath Vandana
Post Graduate Student, Narayana Dental College, and Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India.
Department of Oral and Maxillofacial Pathology and Oral Microbiology, Narayana Dental College, and Hospital, Chinthareddypalem, Nellore, Andhra Pradesh, India.
J Oral Maxillofac Pathol. 2023 Oct-Dec;27(4):663-667. doi: 10.4103/jomfp.jomfp_324_23. Epub 2023 Dec 20.
Type II diabetes mellitus (T2DM) is a metabolic disorder. It is thought to be an autoinflammatory disease, as inflammatory mediators are associated with the progression of the disease. Visfatin, an adipokine, is linked to insulin resistance.
We aimed to study serum and salivary visfatin levels, at the time of diagnosis of T2DM, in middle-aged individuals, in the context of other diagnostic parameters like fasting blood sugar (FBS), postprandial blood sugar (PPBS), and glycated haemoglobin A1c (HbA1c).
Thirty newly diagnosed T2DM (Group-I, T2DM) patients and 30 healthy nondiabetic individuals (Group-II, health controls [HC]) matched for age and sex were studied. In both the groups, we assessed serum and salivary visfatin levels, and serum high-sensitivity C-reactive protein (hs-CRP) levels. We also compared serum and salivary visfatin levels and serum hs-CRP levels between Group-I and Group-II individuals.
The correlation between the groups was tested using Pearson's correlation. A value < 0.001 was considered to be statistically significant. The data was tabulated using software MS Excel and analysed using IBM Statistical Package for the Social Sciences (SPSS) Version 22.0.
A positive correlation with a value of 0.8836 and a value of 0.001 was noted between serum and salivary visfatin of Group-I.
This is the first study in the Indian scenario to study the serum and salivary visfatin in newly diagnosed T2DM individuals. Serum visfatin and hs-CRP levels increased in T2DM, thus defining the link between visfatin, inflammation and T2DM, but we failed to notice a positive correlation.
2型糖尿病（T2DM）是一种代谢紊乱疾病。由于炎症介质与该疾病的进展相关，故被认为是一种自身炎症性疾病。内脂素是一种脂肪因子，与胰岛素抵抗有关。
我们旨在研究中年个体在T2DM诊断时的血清和唾液内脂素水平，并结合其他诊断参数，如空腹血糖（FBS）、餐后血糖（PPBS）和糖化血红蛋白A1c（HbA1c）。
研究了30例新诊断的T2DM患者（第一组，T2DM组）和30例年龄和性别相匹配的健康非糖尿病个体（第二组，健康对照组[HC]）。在两组中，我们评估了血清和唾液内脂素水平以及血清高敏C反应蛋白（hs-CRP）水平。我们还比较了第一组和第二组个体之间的血清和唾液内脂素水平以及血清hs-CRP水平。
使用Pearson相关性检验两组之间的相关性。P值<0.001被认为具有统计学意义。数据使用MS Excel软件制成表格，并使用IBM社会科学统计软件包（SPSS）22.0版进行分析。
第一组血清和唾液内脂素之间的正相关性P值为0.8836，P值为0.001。
这是印度首次针对新诊断的T2DM个体研究血清和唾液内脂素的研究。T2DM患者的血清内脂素和hs-CRP水平升高，从而确定了内脂素、炎症与T2DM之间的联系，但我们未发现正相关性。
