van Schie Mojca K M, Werth Esther, Lammers Gert Jan, Overeem Sebastiaan, Baumann Christian R, Fronczek Rolf
Leiden University Medical Centre, Leiden, The Netherlands.
University Hospital Zurich, Zurich, Switzerland.
J Sleep Res. 2016 Aug;25(4):486-96. doi: 10.1111/jsr.12386. Epub 2016 Feb 23.
This two-centre observational study of vigilance measurements assessed the feasibility of vigilance measurements on multiple days using the Sustained Attention to Response Task and the Psychomotor Vigilance Test with portable task equipment, and subsequently assessed the effect of sodium oxybate treatment on vigilance in patients with narcolepsy. Twenty-six patients with narcolepsy and 15 healthy controls were included. The study comprised two in-laboratory days for the Maintenance of Wakefulness Test and the Oxford Sleep Resistance test, followed by 7-day portable vigilance battery measurements. This procedure was repeated for patients with narcolepsy after at least 3 months of stable treatment with sodium oxybate. Patients with narcolepsy had a higher Sustained Attention to Response Task error count, lower Psychomotor Vigilance Test reciprocal reaction time, higher Oxford Sleep Resistance test omission error count adjusted for test duration (Oxford Sleep Resistance testOMIS / MIN ), and lower Oxford Sleep Resistance test and Maintenance of Wakefulness Test sleep latency compared with controls (all P < 0.01). Treatment with sodium oxybate was associated with a longer Maintenance of Wakefulness Test sleep latency (P < 0.01), lower Oxford Sleep Resistance testOMIS / MIN (P = 0.01) and a lower Sustained Attention to Response Task error count (P = 0.01) in patients with narcolepsy, but not with absolute changes in Oxford Sleep Resistance test sleep latency or Psychomotor Vigilance Test reciprocal reaction time. It was concluded that portable measurements of sustained attention as well as in-laboratory Oxford Sleep Resistance test and Maintenance of Wakefulness Test measurements revealed worse performance for narcoleptic patients compared with controls, and that sodium oxybate was associated with an improvement of sustained attention and a better resistance to sleep.
这项关于警觉性测量的双中心观察性研究，使用便携式任务设备通过持续注意力反应任务和精神运动警觉性测试，评估了多日进行警觉性测量的可行性，随后评估了羟丁酸钠治疗对发作性睡病患者警觉性的影响。纳入了26例发作性睡病患者和15名健康对照者。该研究包括两个实验室日的清醒维持测试和牛津睡眠抵抗测试，随后进行为期7天的便携式警觉性电池测量。在羟丁酸钠稳定治疗至少3个月后，对发作性睡病患者重复此程序。与对照组相比，发作性睡病患者的持续注意力反应任务错误计数更高，精神运动警觉性测试倒数反应时间更低，牛津睡眠抵抗测试遗漏错误计数（牛津睡眠抵抗测试遗漏错误数/分钟）经测试持续时间调整后更高，牛津睡眠抵抗测试和清醒维持测试的睡眠潜伏期更低（所有P<0.01）。羟丁酸钠治疗与发作性睡病患者更长的清醒维持测试睡眠潜伏期（P<0.01）、更低的牛津睡眠抵抗测试遗漏错误数/分钟（P = 0.01）和更低的持续注意力反应任务错误计数（P = 0.01）相关，但与牛津睡眠抵抗测试睡眠潜伏期或精神运动警觉性测试倒数反应时间的绝对变化无关。得出的结论是，与对照组相比，便携式持续注意力测量以及实验室牛津睡眠抵抗测试和清醒维持测试测量显示发作性睡病患者的表现更差，并且羟丁酸钠与持续注意力的改善和更好的睡眠抵抗相关。
